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  • Book
    edited by Riitta Seppänen-Kaijansinkko.
    Summary: This book provides a thorough, up-to-date description of the scientific basis and concepts of tissue engineering in the oral and maxillofacial region. The opening chapters present an introduction to tissue engineering, describe the roles of biomaterials and stem cells, discuss the use of growth factors, and examine potential adverse reactions. The challenges of soft and hard tissue engineering for oral and maxillofacial reconstruction are then considered in detail. It is explained what has been achieved to date, and potential future perspectives are explored. The importance and the verification of adequate vascularization are discussed, and a further focus is the use of 3D printing, both in the planning and production of scaffolds and in the bioprinting of cells and biomaterials. Information is also included on safety, efficacy, and regulatory aspects. Tissue Engineering in Oral and Maxillofacial Surgery will be of interest to all researchers and practitioners who wish to learn more about the potential of tissue engineering to revolutionize practice in oral and maxillofacial surgery.

    Contents:
    Introduction to Tissue Engineering
    Biomaterials for cranio-maxillo-facial bone engineering
    Cells
    Physical stimulation in tissue engineering
    Growth factors
    Tissue Engineering of Composite Soft Tissue Grafts for Craniomaxillofacial Reconstruction
    Hard tissue engineering
    Vascularization in Oral and Maxillofacial Tissue Engineering
    3-D Computer Aided Design and Manufacturing
    Safety, Efficacy and Regulation of Mesenchymal Stromal/Stem Cells
    Future perspectives
    with special emphasis on extracellular vesicles.
    Digital Access Springer 2019
  • Article
    James V.
    Br J Haematol. 1978 May;39(1):17-24.
    With the development of different treatment schedules for acute and chronic leukaemias it has become essential that a uniform, standardized classification of malignant cell type is achieved. Without a standardized diagnosis it is impossible to compare the results of differing treatment regimes. Present diagnosis is still based on clinical criteria and subjective assessment of cell morphology; objective and quantitative data are required. Stereological analyses are capable of providing quantitative data. Stereological techniques have been applied to the study of malignant cell types in different leukaemias for the first time and quantitative data has been obtained. The nuclear and mitochondrial volume fractions of the cells have been estimated for normal lymphocytes, the lymphocytes of chronic lymphocytic leukaemia, acute lymphoblastic leukaemia, the abnormal cells of hairy cell leukaemia and several other haematological malignancies. The results clearly indicate that the cell types fo different leukaemias possess measurably different properties and that stereological methods can be used to investigate the leukaemic cell quantitatively.
    Digital Access Access Options