BookCharlotte Hedin, John D. Rioux, Mauro D'Amato, editors.
Summary: Inflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowledge, with particular focus on the molecular and genetic mechanisms at the basis of IBD. Invited experts, at the frontline of IBD research, introduce basic concepts in the pathophysiology of IBD and its two major forms Crohn's disease and ulcerative colitis, provide a historical perspective and highlight latest discoveries of IBD genetic research, describe how this information has helped to unravel novel pathogenetic pathways, and formulate a vision for future investigations and their clinical application in IBD. State-of-the-art information contained in this book is an exceptional resource for all those in the biomedical field with a specific interest in IBD, including basic scientists, gastroenterologists, GI specialist doctors and research nurses, but also medical and biomedical students.
Contents:
Part 1: The Foundation of IBD Genetics, Human and Animal Studies
A Primer on IBD: Phenotypes, Diagnosis, Treatment and Clinical Challenges
Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies
Insights from Recent Advances in Animal Models of Inflammatory Bowel Disease
Part 2: The Genetic and Molecular Makeup of Inflammatory Bowel Disease
Complex Disease Genes and their Discovery
The Genetics of Crohn's Disease
Genetics of Ulcerative Colitis
Genetic Overlap between Inflammatory Bowel Disease and Other Diseases
Molecular Profiling of IBD Subtypes/Response to Therapy
Epigenetics of Inflammatory Bowel Disease
Part 3: Pathogenetic Pathways in Inflammatory Bowel Disease
Nod1 and Nod2 and the Immune Response to Bacteria
The IL-23-Th17 Axis in Intestinal Inflammation
Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics
The Epithelial Barrier
Host Interactions with Bacteria: From "Entente Cordiale" to "Casus Belli"
Cytokines in Inflammatory Bowel Disease
Part 4: Concluding Remarks and Future Perspectives
Towards Personalized Therapy in Inflammatory Bowel Disease
Index.