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  • Book
    K.V. Chaitanya.
    Summary: This book provides a detailed and up-to-dated information on the genomes belonging to three major life forms on Earth - archaea, prokaryotes and eukaryotes. Each section describes about the genome of a specific group of organisms, such as viruses, archaea, bacteria, eukaryotes and organellar genomes. Individual chapters provide details of their organization, structure, evolution, sequencing strategies and functions. Further, this book discusses the technologies that are applied for genome sequencing; assembly, annotation and gene prediction. Other topics include the genomes of important model organisms, mitochondria genome of Neanderthal fossil, etc. This book also examines the evolution of chloroplast and mitochondria genomes by comparing with bacteria, addresses the diseases that occur in humans due to the mutations in mitochondrial genome, gene therapy and engineering of chloroplast and mitochondrial genomes. Lastly, it features an overview of the role of proteomics, exposomics, connectomics, metabolomics, and microbiomics. This book is a fascinating read for students, lecturers and researchers in the field of genetics, genomics, microbiology and life sciences.

    Contents:
    Chapter 1. Structure and Organization of Virus Genomes
    Chapter 2. Archaeal Genomics
    Chapter 3. Structure, Function, and Evolution of Bacterial Genomes
    Chapter 4. Organellar Genome Analysis
    Chapter 5. Eukaryotic Genome Organization, Regulation, Evolution, and Control
    Chapter 6. Genome sequencing, Assembly and Annotation
    Chapter 7. Other Omics Integrated into Biosciences
    Chapter 8.Application of genomics
    Chapter 9. Important Databases Related to the Genomes.
    Digital Access Springer 2019
  • Article
    Talal N.
    Arthritis Rheum. 1978 Jun;21(5 Suppl):S58-63.
    Pathologic and immunologic features of the spontaneous autoimmune disease of NZB and NZB/NZW F1 (B/W) mice resemble human SLE in three major respects: formation of antibodies to nucleic acids, deposition of immune complexes containing DNA in the kidney, and earlier onset of severe disease in females. Genetic, viral, and hormonal factors are involved in a pathogenetic mechanism that is manifest primarily as a disturbance in immunologic regulation. Recent studies on the sequential development of IgM and then IgG antibodies to DNA and RNA suggest that the thymus, spleen, and gonads exert important regulatory influences. We have found that sex hormones modulate the expression of autoimmunity in B/W mice, with androgens suppressing and estrogens accelerating disease. The hormones may act by restoring immunologic control.
    Digital Access Access Options