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- BookDaan J.A. Crommelin, Robert D. Sindelar, Bernd Meibohm, editors.Summary: This introductory text explains both the basic science and the applications of biotechnology derived pharmaceuticals, with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate/graduate pharmacists, pharmaceutical science students, and for those who did not receive formal training in this field. Pharmaceutical Biotechnology: Fundamentals and Applications, Fifth Edition completely updates the previous edition, and includes additional coverage on newer approaches such as oligonucleotides, mi/siRNA, gene therapy and advanced therapeutics.
Contents:
Molecular Biotechnology
Biophysical and biochemical analysis of recombinant proteins
Production and downstream processing of biotech products
Formulation of biotech products, including biopharmaceutical considerations
Pharmacokinetics and pharmacodynamics of peptide and protein drugs
Immunogenicity of pharmaceutical proteins
General considerations of monoclonal antibodies from structure to therapeutic application
Genomics, Other "Omics" Technologies, Personalized Medicine and Additional Biotechnology-Related Techniques
Dispensing biotechnology products: handling, professional education and product information
Economic considerations in medical biotechnology
Regulatory framework for biosimilars
Vaccines
Oligonucleotides and siRNA
Gene therapy
Stem cell technology
Therapeutic Applications.-Endocrinology
Insulin
Follicle-stimulating hormone
Growth hormone
Cardiovascular and Respiratory Applications
Recombinant coagulation factors and thrombolytics
Recombinant human deoxyribonuclease
Oncology
Monoclonal antibodies in oncology
Hematopoetic growth factors
Inflammation and Immunemodulation
Monoclonal antibodies in transplantation
Monoclonal antibodies and antibody-based therapeutics in anti-inflammatory therapy
Interferons and interleukins
Anti-infectious diseases
Monoclonal antibodies
Enzyme replacement therapy. - ArticleShargorodskiĭ AG.Stomatologiia (Mosk). 1978 May-Jun;57(3):93-6.