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- JournalSummary: Presenting original manuscripts related to nursing and healthcare.Digital Access CINAHL v. 18, no. 2-, Apr.-June 2014-
- JournalDigital AccessProviderVersionFull text via HathiTrust
- ArticleRiley M, Solomon L, Zipkas D.J Mol Evol. 1978 May 12;11(1):47-56.Genes of Escherichia coli were grouped according to the "biochemical relatedness" of the enzymes they specifiy, using two schemes to determine relatedness: similarity of reaction or similarity of reactants. The tendency of biochemically related genes as so defined to lie approximately 90 degrees or 180 degrees from one another on the circular genetic map was analyzed statistically. Of the classes analyzed, only the genes for the enzymes of glucose catabolism showed a significant departure from random distribution in this respect. The glucose catabolism genes showed a pronounced tendency to lie either 90 degrees of 180 degrees from one another (P = ca. 10(-9)), and, furthermore, most of these genes were found to lie in only four gene clusters on the E. coli genome. The significance of this observation is discussed in relation to evolutionary mechanisms and to mechanisms of gene expression.