BookBingyun Li, Thomas Webster, editors.
Summary: This book covers the latest progress in the biology and manufacturing of orthopedic biomaterials, as well as key industry perspectives. Topics covered include the development of biomaterial-based medical products for orthopedic applications, anti-infection technologies for orthopedic implants, additive manufacturing of orthopedic implants, and more. This is an ideal book for graduate students, researchers and professionals working with orthopedic biomaterials and tissue engineering. This book also: Provides an industry perspective on technologies to prevent orthopedic implant related infection Thoroughly covers how to modulate innate inflammatory reactions in the application of orthopedic biomaterials Details the state-of-the-art research on 3D printed porous bone constructs.
Contents:
Intro; Preface; Contents; Part I: Design, Manufacturing, Assessment, and Applications; Nanotechnology for Orthopedic Applications: From Manufacturing Processes to Clinical Applications; 1 Introduction; 2 The Extracellular Matrix (ECM); 2.1 ECM Composition; 2.2 The ECM as a Molecular Reservoir; 2.3 Cell-ECM Interactions; 2.4 Bone; 2.4.1 Cortical Bone; 2.4.2 Cancellous Bone; 3 Tissue Engineering; 3.1 Nanotechnology for Tissue Engineering; 3.2 Control of Cell Functions Using Nanotechnology; 3.3 Cell Sensitivity to Nanofeatures; 3.4 Important Features of Scaffolds for Tissue Engineering. 3.1.3 Titanium Alloys3.1.4 Tantalum; 3.2 Other Biomaterials; 3.2.1 PEEK; 3.2.2 Ceramics; 4 AM Design Considerations; 4.1 Patient-Specific Design Procedures; 4.2 Porosity; 4.3 Clinical Applications; 4.4 Patient Variability; 4.5 Shoulder and Other Joint Replacements; 4.6 Fracture Fixation; 4.7 Large Bone Defects; 4.8 Surgical Guides; 4.9 Additional Clinical Examples; 5 Summary; References; 3D Printed Porous Bone Constructs; 1 Introduction; 2 3D Printing Techniques; 3 Porous Materials for Cell Growth; 4 3D Printing of Porous Ceramic Materials; 5 3D Printing of Porous Metal Materials. 3.5 Materials for Scaffold Construction4 Unmet Clinical Need; 4.1 Substrate Properties for Osseointegration; 4.2 Substrate Properties to Resist Bacterial Infection; 4.2.1 Shot Peened 316 L Stainless Steel; 4.2.2 Electrophoretic Deposition; 5 Conclusions; References; Additive Manufacturing of Orthopedic Implants; 1 Introduction; 2 Additive Manufacturing Techniques; 2.1 Binder Jetting; 2.2 Directed Energy Deposition (DED); 2.3 Powder Bed Fusion (PBF); 2.4 Material Extrusion; 3 Additively Manufactured Biomaterials; 3.1 Metallic Biomaterials; 3.1.1 Stainless Steel; 3.1.2 Co-Cr Alloys. 6 3D Printing of Porous Polymer Materials7 Conclusions; References; Biopolymer Based Interfacial Tissue Engineering for Arthritis; 1 Introduction; 2 Anatomy of Osteochondral Tissue Interface; 3 Conventional Vs. Interfacial Tissue Engineering; 4 Polymeric Biomaterials for Interfacial Tissue Engineering; 5 Design Considerations for Interfacial Tissue Engineering; 5.1 Stratified Scaffold Design; 5.2 Gradient Scaffold Design; 6 Present Clinical Status of Interfacial Tissue Engineering; 7 Future Perspectives of Interfacial Tissue Engineering in Orthopedic Applications; 8 Conclusion; References. Performance of Bore-Cone Taper Junctions on Explanted Total Knee Replacements with Modular Stem Extensions: Mechanical Disassembly and Corrosion Analysis of Two Designs1 Introduction; 2 Materials and Methods; 2.1 Implant Retrieval and Archiving; 2.2 Assessment of Surface Corrosion Area; 2.3 Damage Mode Characterization; 2.4 Data Analysis; 3 Results; 4 Discussion; 4.1 Effects of Design and Modes of Corrosion; 4.2 Effects of Patient Factors and Anatomical Location; 4.3 Mechanical Disassembly and Surface Corrosion Area; 4.4 Limitations; 5 Conclusion; References.