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  • Book
    Luis Olivares-Quiroz, Osbaldo Resendis-Antonio, editors.
    Summary: This book presents cutting-edge research on the use of physical and mathematical formalisms to model and quantitatively analyze biological phenomena ranging from microscopic to macroscopic systems. The systems discussed in this compilation cover protein folding pathways, gene regulation in prostate cancer, quorum sensing in bacteria to mathematical and physical descriptions to analyze anomalous diffusion in patchy environments and the physical mechanisms that drive active motion in large sets of particles, both fundamental descriptions that can be applied to different phenomena in biology. All chapters are written by well-known experts on their respective research fields with a vast amount of scientific discussion and references in order the interested reader can pursue a further reading. Given these features, we consider Quantitative Models for Microscopic to Macroscopic Biological Macromolecules and Tissues as an excellent and up-to-date resource and reference for advanced undergraduate students, graduate students and junior researchers interested in the latest developments at the intersection of physics, mathematics, molecular biology, and computational sciences. Such research field, without hesitation, is one of the most interesting, challenging and active of this century and the next.

    Contents:
    Diverse protein-folding pathways and functions of beta-hairpins and beta-sheets
    MicroRNAs, gene's regulator in prostate cáncer
    Subdiffusive Transport in Heterogeneous Patchy Environments
    Molecular assembling of the bacterial injectisome: a nanomachine used to inject effector proteins
    Pressure-driven DNA denaturation: state of the art and perspectives
    In silico identification and gene expression analysis of CDF-like genes from Trichomonas vaginalis in response to Zinc
    Dynamical features of a biochemical interaction in a plant root hair cell; a long story short
    Homeostasis from a time-series perspective: An intuitive interpretation of the variability of physiological variables
    Looking for biomarkers in physiological time series
    Systems Biology, Metabolomics and Breast Cancer: Where we are and which is the possible destination in the clinic
    Local effective temperatures for the patterns of motion of active particles.
    Digital Access Springer 2018
  • Article
    Murasugi A, Takemura S.
    J Biochem. 1978 Apr;83(4):1029-38.
    Two species of 32P-labelled leucine tRNA were highly purified from Candida (Torulopsis) utilis by successive column chromatographies. The purified major species of leucine tRNA 1 was completely digested with ribonuclease T1 [EC 3.1.4.8] and with pancreatic ribonuclease A [EC 3.1.4.22]. The resulting fragments were fractionated, and their nucleotide sequences were determined according to Barrell (1). The results of analyses of the two ribonuclease digests were consistent with each other, and indicated that this tRNA is composed of 85 nucleotide residues, including 14 modified nucleotides. A tentative total sequence has been derived on the basis of several features in the cloverleaf structure for tRNA.
    Digital Access Access Options