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  • Book
    David Aitchison Smith.
    Contents:
    Intro; Preface; Acknowledgements; Contents;
    Chapter 1: Introduction; 1.1 Historical Perspectives; 1.1.1 The Sliding Filament Model; 1.1.2 New Experimental Techniques; 1.1.3 Models of Contractility; 1.2 A Short Guide to Contractile Behaviour; 1.3 The Structure of Skeletal Muscle; 1.3.1 Muscle Ultrastructure; References;
    Chapter 2: Of Sliding Filaments and Swinging Lever-Arms; 2.1 Contractile Empiricism: Hillś Equations; 2.2 How Myosin Heads Find Actin Sites; 2.2.1 Head-Site Matching for Vernier Models; 2.2.2 Lattice Models: Target Zones, Layer Lines and Azimuthal Matching 2.3 The First Sliding-Filament Model2.4 The Swinging-Lever-Arm Mechanism; 2.4.1 Mechanokinetics of the Working Stroke; 2.4.2 Theory of the Rapid Length-Step Response; References;
    Chapter 3: Actin-Myosin Biochemistry and Structure; 3.1 How Myosin and Actin Hydrolyze ATP; 3.1.1 Myosin is an ATPase; 3.1.2 Actomyosin is a Better ATPase; 3.1.3 Steady-State ATP Hydrolysis by Actin-Myosin; 3.2 The Biochemical Contraction Cycle; 3.2.1 Actin Binding Versus Nucleotide Binding; 3.2.2 A Biochemical Cycle for Myosin-S1; 3.2.3 Evidence for Two A.M. ADP States; 3.2.4 Evidence for Two M. ATP States 3.3 Coordinating Lever-Arm Movements with Biochemical Events3.3.1 What Biochemical Event Triggers the Working Stroke?; 3.3.2 The Location of the Repriming Stroke; 3.3.3 An Amalgated Mechanochemical Cycle; 3.4 The Atomic Structure of Myosin Complexes; 3.4.1 Actin Binding; 3.4.2 Phosphate Release and the Working Stroke; 3.4.3 An ADP-Release Stroke; 3.4.4 ATP Binding and Actin Affinity; 3.4.5 The Repriming Stroke and Hydrolysis; 3.4.6 Hydrolysis on Actomyosin?; 3.4.7 The Pathway of the Stroke; References;
    Chapter 4: Models for Fully-Activated Muscle; 4.1 Strain-Dependent Kinetics 4.1.1 Kramers' Method for Reaction Rates; 4.1.2 Actin Binding: Swing, Roll and Lock; 4.1.3 The Kinetics of the Working Stroke; 4.1.4 An ADP-Release Stroke; 4.2 The Evolution of Contraction Models; 4.2.1 A Two-State Stroking Model; 4.2.2 The Search for a Simple Vernier Model; 4.2.3 Lattice Models; 4.3 Computational Methods; 4.3.1 Probabilistic Methods; 4.3.2 Monte-Carlo Simulation; 4.4 The Effects of Filament Elasticity; 4.4.1 The Equivalent Lumped Filament Compliance; 4.4.2 Experimental Consequences; 4.5 Target Zones, Dimeric Myosins and Buckling Rods 4.5.1 Calculations with Target Zones and Dimeric Myosins4.5.2 An Updated 5-State Vernier Model; 4.5.3 Buckling Rods; 4.6 Adding Phosphate, ADP or ATP; 4.6.1 Added Phosphate; 4.6.2 Changing ADP or ATP; 4.7 The Effects of Temperature; References;
    Chapter 5: Transients, Stability and Oscillations; 5.1 Chemical Jumps and Temperature Jumps; 5.1.1 The Activation Jump; 5.1.2 Pi Jumps; 5.1.3 ATP Jumps; 5.1.4 Temperature Jumps; 5.2 Length Steps; 5.2.1 The Length-Step Response; 5.2.2 Repeated Length Steps; 5.3 Sinusoidal Length Changes; 5.4 Force Steps; 5.4.1 Isotonic Oscillations
    Digital Access Springer 2019
  • Article
    Frisch SM, Couch JL, Glaser DA.
    J Bacteriol. 1978 Jun;134(3):1192-4.
    A mutant of Escherichia coli (sof) which was previously shown to have increased recombination frequency, to produce abnormally short "Okazaki fragments," and to be deficient in deoxyuridine triphosphatase has now been found also to possess mutator activity for several genes; point mutation rates and deletion rates are affected. The mutational stimulation effects are consistent with the hypothesis that incorporation of uracil into DNA is directly or indirectly responsible for the observed mutator activity.
    Digital Access Access Options
  • Book
    Summary: "Directory of constituent societies" included in each Proceeding number. Includes the council's Proceedings.
    Print no. 1-50; Oct. 1920-Apr. 1957.