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  • Book
    by Peter S. Walker.
    Summary: Spanning both the history and future of knee replacement, this unique book recounts how artificial knees have reached the stage they are today, and whether their performance can be further improved. The author, who has been designing artificial knees for 50 years, starts the story in the late 1960's with the early pioneers; during the 1970's, the principles for successful artificial knees were established. While many different types were designed, a small number have become by far the most widely utilized. Yet other types of designs, so far little used, along with new materials and the application of computer-assisted surgery, could result in significant advancements in the treatment of knee arthritis. Each chapter provides a detailed description of the origins of the ideas and principles and their rationale, followed by the latest information and evidence. The book begins with an overview of the history and background of the artificial knee, in terms of design and implementation and the thought leaders involved. Fixation, biomechanics, and the types of designs are discussed in detail, both what has worked and what has not, and why. Instrumentation, testing and tribology, and functional evaluation methods are also covered. The book concludes with a look toward the future possibilities for the field of artificial knees. An illustrated glossary of terms, is included for quick reference. The Artificial Knee: An Ongoing Evolution will appeal to orthopedic surgeons and researchers, medical academics and orthopedic companies, and to those with a general interest in artificial knees.

    Contents:
    Introduction
    Early Biomechanical Knowledge
    The Design Process
    Laxity and Stability
    Fixation Using Acrylic Cement
    Uncemented Fixation
    Femoral Components and Patella
    Tibial Components
    Condylar Replacements
    Posterior Stabilized
    Guided Motion Knees
    Instrumentation and Technique
    Testing and Tribology
    Comparisons of Function between Designs and Techniques
    Discussion and Future Possibilities
    Glossary of Terms.
    Digital Access Springer 2020
  • Article
    Siniukhin VN, Kolesnik TF, Simonova TA, Pochatov IuM.
    Farmakol Toksikol. 1978 May-Jun;41(3):289-91.
    In patients presenting mitral and aortal valvular defects with contemplated valve prosthetics it was shown that after an intravenous administration of azabutyrone in a dose of 4 mg/kg the drug produced a hypotensive effect in the large circulation, reduced insignificantly the cardiac output, venous pressure and the total peripheral resistance, inducing, at the same time, a short-term rise of the heart rate. The drug forced down materially (by more than 50 per cent) the pulmonary artery pressure in patients with pulmonary hypertension. The azabutyrone effects were seen to continue for 30 minutes with its blood plasma concentration of 1.5--3.0 gamma/ml. A clearcut correlation between the plasma content and the effect of the drug could be noted only as concerns the hypotensive action of azabutyrone in the lesser circulation.
    Digital Access Access Options