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  • Book
    Joshua M. Sharfstein.
    Contents:
    Elixir sulfanilamide
    Thalidomide
    The swine flu of 1976
    HIV
    Recognizing a crisis
    Crisis management
    Communications and politics
    Preventing the next crisis
    Responsibility and blame
    Opportunity in crisis
    Supplementary materials : a closer look at crises.
  • Article
    Arimura A, Pedroza E, Vilchez-Martinez J, Schally AV.
    Endocr Res Commun. 1977;4(6):357-66.
    Effect of large doses of [D-Trp6]-LH-RH and HCG on implantation of fertilized ova was examined in the rat. Subcutaneous administration of 6ug[D-Trp6]-LH-RH per day from days 1 to 5 of pregnancy by an implanted minipump completely prevented the implantation of fertilized ova associated with a dramatic reduction of plasma progesterone on days 4 and 8, with a slight reduction of estradiol on day 4. There was no balooning of the uterus in the exploratory laparatomy on days 8 and 14. Administration of 1000 U of HCG daily from days 1 to 5 partially prevented implantation and completely terminated gestation. However, plasma progesterone and estradiol levels did not differ from those in the control animals. Ovaries in the [D-Trp6]-LH-RH treated rats appeared to be the same in size as those of the control pregnant rats, whereas the ovaries of the HCG-treated rats were hypertrophied. The results suggest that [D-Trp6]-LH-RH prevents nidation through a mechanism different from that for the adverse effect of excess of HCG on pregnancy.
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