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  • Book
    Grant S. Fletcher.
    Summary: "This book is for clinicians-physicians, nurses, physicians' assistants, psychologists, veterinarians, and others who care for patients-who want to understand for themselves the strength of the information base for their clinical decisions"-- Provided by publisher.

    Contents:
    -- Frequency
    Abnormality
    Diagnosis
    Risk: Basic Principles
    Risk: Exposure to Disease
    Risk: From Disease to Exposure
    Prognosis
    Treatment
    Prevention
    Chance
    Cause
    Summarizing the Evidence
    Knowledge Management
    Digital Access
    Provider
    Version
    Ovid
    2021
    LWW Health Library (Medical Education)
    2021
  • Article
    Calos MP, Johnsrud L, Miller JH.
    Cell. 1978 Mar;13(3):411-8.
    We have detected two independent occurrences of insertion mutations in the lacl gene of E. Coli, and have used small plasmids carrying the l gene to purify large amounts of DNA containing these insertions. Analyses with restriction endonucleases and DNA sequencing techniques establish that both insertions involve the previously characterized element IS1. In each case, the integration of IS1 into the l gene DNA is associated with a directly repeated sequence of 9 nucleotides appearing at each end of the insertion element. Since one of these sequences was present in the wild-type gene, the second sequence either preexisted in the IS1 before integration, or else was generated by the process of insertion itself. The 9 base repeat is different in both cases. We discuss the relevance of these findings to the mechanism of integration of transposable elements.
    Digital Access Access Options