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  • Book
    National Council of State Boards of Nursing (NCSBN), Expert Panel on Practice Breakdown ; Patricia E. Benner, Kathy Malloch, Vickie Sheets, editors ; Karla Bitz [and others].
    Contents:
    Overview : NCSBN practice breakdown initiative
    Practice breakdown : medication administration
    Practice breakdown : clearly communicating patient data and clinical assessments
    Practice breakdown : attentiveness/surveillance
    Practice breakdown : clinical reasoning or judgment
    Practice breakdown : prevention
    Practice breakdown : intervention
    Practice breakdown : interpretation of authorized provider orders
    Practice breakdown : professional responsibility and patient advocacy
    Mandatory reporting
    Organizational use of TERCAP : shifting from a quality management to a whole systems approach.
    Digital Access ClinicalKey Nursing 2010
  • Article
    Opheim DJ.
    Biochim Biophys Acta. 1978 May 11;524(1):121-30.
    A unique and interesting alpha-D-mannosidase (alpha-D-mannoside mannohydrolase EC 3.2.1.24) activity has been isolated from Saccharomyces cerevisiae. The enzyme was localized in a crude particulate fraction of the cell extract and was not solubilized by treatment with detergents or high ionic strength NaCl. The enzyme had a pH optimum of 6.3, Km 50 micron with p-nitrophenyl-alpha-D-mannopyranoside, and was competitively inhibited by D-mannose (Ki 20 mM). The enzyme is not affected by ethylenediaminetetraacetic acid, a number of different cations, or sulfhydryl reagents. It was inhibited by p-chloromercuriphenyl sulfonic acid and this inhibition is prevented by the addition of substrate. The cellular concentration of alpha-D-mannosidase is inversely proportional to growth rate, suggesting that the enzyme is under catabolite repression. The level of enzyme was found to increase approx. 8-fold during sporulation. This is apparently due to de novo synthesis, since inhibition of protein synthesis by cycloheximide prevents the increase in enzyme activity.
    Digital Access Access Options