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  • Book
    Mary Fran Hazinski, RN, MSN, FAAN, FAHA, FERC, Professor, ... Show More Vanderbilt University School of Nursing, Assistant Departments of Surgery and Pediatrics, Vanderbilt University School of Medicine, Clinical Nurse Specialist, Pediatric Critical Care, Monroe Carell, Jr, Children's Hospital at Vanderbilt, Nashville, Tennessee.
    Summary: "Now completely up to date to meet the needs of today's pediatric nurses, Mary Fran Hazinski's Nursing Care of the Critically Ill Child, 3rd Edition, remains the foundational text of pediatric critical care nursing. Known for its outstanding organization and clear descriptions, this comprehensive reference details the unique care required for critically ill children with thorough discussions of physiology, pathophysiology, pharmacology, collaborative management, and nursing management. Ten new chapters, new advanced practice content, and new nurse contributors and reviewers ensure that this classic text continues to be the essential resource for the care of critically ill children." -- Publisher.

    Contents:
    Children are different
    Psychosocial aspects of pediatric critical care
    Care of the child with life-limiting conditions in the pediatric intensive care unit
    Pharmacokinetics and pharmacodynamics
    Analgesia, sedation, and neuromuscular blockade
    Shock, cardiac arrest, and resuscitation
    Mechanical support of cardiopulmonary function: extracorporeal membrane oxygenation (ECMO) and ventricular assist devices
    Cardiovascular disorders
    Pulmonary disorders
    Chest x-ray interpretation
    Neurologic disorders
    Fluid, electrolyte, and endocrine problems
    Renal and kidney disorders
    Gastrointestinal and nutritional disorders
    Hematologic and oncologic emergencies requiring critical care
    Immunology and infectious disorders
    Transplantation and organ donation
    Toxicology/poisonings
    Pediatric trauma
    Care of the child with burns and wounds
    Bioinstrumentation
    Fundamentals of quality improvement and patient safety
    Clinical informatics
    Ethics.
    Digital Access ClinicalKey Nursing 2013
  • Article
    Averbeck D, Moustacchi E, Bisagni E.
    Biochim Biophys Acta. 1978 May 23;518(3):464-81.
    A newly synthesized linear psoralen derivative, 3-carbethoxypsoralen is shown to bind to yeast nucleic acids after 365 nm light treatment. As compared to 8-methoxypsoralen, a well-known bifunctional furocoumarin, 3-carbethoxypsoralen exhibits a high photoaffinity for DNA in vivo. Both compounds bind and photoreact more efficiently in vivo than in vitro. In contrast to 8-methoxypsoralen, 3-carbethoxypsoralen does not form cross-links in yeast DNA as demonstrated by heat denaturation-reassociation studies at least in the range of doses used. Thus 3-carbethoxypsoralen reacts as a monofunctional compound. Wild-type cells of Saccharomyces cerevisiae are 6 times more resistant to 3-carbethoxypsoralen than to 8-methoxypsoralen plus 365 nm light treatment in terms of lethal effect. In comparison to angelicin, another monofunctional (but angular) furocoumarin, 3-carbethoxypsoralen is more photoreactive. When the photoaffinity for DNA of 8-methoxypsoralen and 3-carbethoxypsoralen are considered in relation to photoinduced cell killing, it is clear that monoadducts are very efficiently repaired in wild-type cells. In contrast to the additivity obtained with 8-methoxypsoralen, a synergistic interaction of the two different repair pathways blocked by the rad2 and the rad9 mutation is observed after 3-carbethoxypsoralen plus 365 nm light. Dark holding experiments show that the excision repair function which is present in wild-type and rad9-4 cells is important for dark recovery.
    Digital Access Access Options
  • Journal
    Print 1958-61.