BookPhilip S. Zeitler, Kristen J. Nadeau, editors.
Contents:
Intro; Series Editor Foreword; Reference; Preface to the Second Edition; Contents; Editors; Contributors; Part I: Definition and Epidemiology;
1: Clinical Manifestations of Insulin Resistance in Youth; Introduction; Metabolic Effects of Insulin; Insulin Resistance; Contributory Factors to Developing Insulin Resistance; Non-modifiable Factors; Puberty; Genetics; Epigenetics; Ethnicity; Modifiable Factors; Obesity; Diet and Lifestyle; Physical Activity; Conditions Associated with Insulin Resistance; Metabolic Syndrome; Prediabetes and Type 2 Diabetes; Polycystic Ovary Syndrome (PCOS) Nonalcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH)Lipodystrophies: Inherited and Acquired; Interventional Options; Conclusions; References;
2: Techniques to Assess Insulin Action in Youth; Assessing Insulin Sensitivity; Techniques; Insulin-Glucose Clamp Technique; Hyperinsulinemic-Euglycemic Clamp; Hyperglycemic Clamp; Use of Isotopes and Indirect Calorimetry with the Insulin-Glucose Clamp Technique; The Frequently Sampled Intravenous Glucose Tolerance Test with Minimal Model Analysis; Oral Glucose Tolerance Test Surrogate Estimates of Insulin Sensitivity and SecretionFasting Estimates of Insulin Sensitivity and Secretion; Estimates of Insulin Sensitivity and Secretion During the Oral Glucose Tolerance Test; Methodologies Not Currently Practiced in Pediatrics; Summary; References;
3: Insulin Resistance in Chronic Disease; Introduction; Asthma; Obesity Can Predate Asthma; Obesity in Persons with Asthma; Asthma and Insulin Resistance; Asthma and the Metabolic Syndrome; Significance and Treatment; Type 1 Diabetes Mellitus; Obesity Predates the Development of Type 1 Diabetes Mellitus Obesity Among Children and Adolescents with Type 1 Diabetes MellitusInsulin Resistance Among Type 1 Diabetes Mellitus Individuals; Metabolic Syndrome Among Type 1 Diabetes Mellitus Individuals; Significance and Treatment; Cancer Survivors; Components of the Metabolic Syndrome May Be Detected Within the First Years After Hematopoietic Stem Cell Transplantations; Overweight, Obesity, Sarcopenic Obesity, and the Metabolic Syndrome; Factors Associated with Increased Risk of Developing the Metabolic Syndrome; Significance; Psychiatric Disorders; Obesity Predates Psychiatric Disorders Persons with Psychiatric Disease Are at Higher Risk of Being Obese;The Metabolic Syndrome in Psychiatric Disorders; Significance and Treatment; Epilepsy; Are Overweight and Obesity More Prevalent in Individuals with Epilepsy?; Insulin Resistance and Epilepsy; Metabolic Syndrome in Epilepsy; Multiple Sclerosis; Classical Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency; Steroids; Other Common Medications Associated with the Metabolic Syndrome; Summary; References; Part II: Pathophysiology;
4: Molecular Mechanisms of Insulin Resistance; Serine Phosphorylation of IRS-1