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  • Book
    Jun Cui, editor.
    Summary: This book discusses novel concepts and discoveries concerning the regulation of innate immunity by autophagy and autophagy-related proteins. In the past decade, there have been major advances in our understanding of the molecular mechanisms of autophagy and its physiological functions. This book highlights emerging studies on the underlying mechanisms of autophagy regulation of innate immunity, including inflammation, antiviral immunity and anti-bacterial responses and the signaling pathways that prompt or inhibit the initiation and progression of related diseases. It also offers new ideas and strategies for future drugs based on manipulating autophagy, especially selective autophagy mediated by cargo receptors. Providing a comprehensive overview of the autophagy regulation of innate immunity, it is a valuable resource for graduate students and researchers in the fields of immunology, cell biology and translational medicine.

    Contents:
    Introduction
    Autophagy Regulation of Mammalian Immune Cells
    Autophagy in Plant Immunity
    Autophagy Regulation of Bacterial Pathogen Invasion
    Autophagy and viral infection
    The Interplay between Pattern Recognition Receptors and Autophagy in Inflammation
    Regulation of Inflammasome by Autophagy
    The Cross-regulation between Autophagy and Type I Interferon Signaling in Host Defense
    Selective Autophagy Regulates Innate Immunity through Cargo Receptor Network
    Autophagy and Immune-related Diseases
    Targeting Autophagy with Small-molecule Modulators in Immune-related diseases.
    Digital Access Springer 2019
  • Article
    Meda P.
    Diabetologia. 1978 May;14(5):305-10.
    Lysosomes and their relationships with surrounding organelles were studied in pancreatic B-cells of normal Wistar rats by electron microscopy and cytochemical localization of acid phosphatase (AcPase) and arylsulphatase. Several forms of lysosomes were distinguished and shown to interact frequently with the secretory granules. Two different digestive processes were recognized. During crinophagy, lysosomes directly fuse with secretory granules while, during autophagy, a cytoplasmic area containing secretory granules and/or other organelles is circumscribed before the enzymatic digestion. In addition, lysosomes may transport arylsulphatase into secretory granules apparently not involved in a destructive process. Such a process could also account, at least in part, for the presence of AcPase in a certain number of mature and immature secretory granules.
    Digital Access Access Options