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• Book

  Problem solving in chest imaging

  [edited by] Subba R. Digumarthy, Suhny Abbara, Jonathan H. Chung.

  Digital Access ClinicalKey 2019
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• Article

  Phase II study of cis-dichlorodiammineplatinum(II) in advanced breast cancer.

  Yap HY, Salem P, Hortobagyi GN, Bodey GP, Buzdar AU, Tashima CK, Blumenschein GR.

  Cancer Treat Rep. 1978 Mar;62(3):405-8.

  Twenty-six patients with metastatic breast cancer received cis-dichlorodiammineplatinum(II) either as a single dose of 100 mg/m2 iv every 3--4 weeks or as a continuous 5-day infusion of 20 mg/m2/day at 4-week intervals. Fourteen patients were treated with the single-dose schedule and 12 patients were treated with the continuous 5-day infusion. No significant response was observed with either dose schedule. Aside from a reduction in the frequency and severity of gastrointestinal toxicity with the continuous 5-day infusion, no real difference was seen with regard to renal and hematologic toxicity with either dose schedule.

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  PubMed