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  Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy : A Comprehensive Guide

  edited by Daniel M. Trifiletti, Samuel T. Chao, Arjun Sahgal, Jason P. Sheehan.

  Summary: This book is a comprehensive review of stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT): its physics, clinical evidence, indications, and future directions. The utilization of stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) is increasing internationally because of several factors. First, it offers patients a local treatment option that has demonstrated effectiveness similar to traditional surgery without the morbidity of general anesthesia and open surgical resection. Second, recent advancements in the quality of scientific evidence supporting a SRS or SBRT-containing approach in patients continues to evolve and demonstrate favorable disease-specific outcomes with little, if any, toxicity in various anatomic disease sites and for various conditions including cancer, benign tumors, and other psychiatric and neurologic conditions. Third, and most provocatively, is the notion that definitive local therapy (i.e. SRS or SBRT) in patients with cancer can boost the immune system to fight cancer in other sites throughout the body. While traditional medical knowledge would suggest that all patients with metastatic cancer are incurable, there is a mounting body of evidence that there is a subset of these patients that can be cured with definitive SRS or SBRT. This volume thus delves into each of these benefits and aspects of treatment, guiding physicians to the best treatment plan for their patients. Expert, international authors provide guidelines for SRS and SBRT use by clinicians. Chapters are divided into six main sections: Radiobiology of Radiosurgery and Stereotactic Body Radiation Therapy, Intracranial Radiosurgery Technique, Intracranial Radiosurgery by Indication, Stereotactic Body Radiation Therapy Technique, Stereotactic Body Radiation Therapy by Indication, The Future of Radiosurgery and SBRT. Overall physics are explained, as well as specific considerations for particular surgical tools (including the L eksell Gamma Knife and Accuray CyberKnife), techniques (including fractionated and charged particle radiosurgery), and anatomic sites (including brain metastases, pituitary tumors, and the prostate). Detailed images and charts enhance the chapters. This book provides physicians with a single, practical resource incorporating both of these broad categories of treatment, SRS and SBRT, and better defines the current role and the direction of radiosurgery.
  
  Contents:
  Section I: Radiobiology of Radiosurgery and Stereotactic Body Radiation Therapy
  Vascular-Mediated Mechanisms
  Immune-Mediated Mechanisms
  Rationale for Fractionated and Single Session Approaches
  Section II: Intracranial Radiosurgery Technique
  Physics of Radiosurgery
  Leksell Gamma Knife Radiosurgery
  Accuray CyberKnife Robotic Radiosurgery
  Linear Accelerator-Based Radiosurgery
  Fractionated Radiosurgery
  Charged Particle Radiosurgery
  Section III: Intracranial Radiosurgery by Indication
  Brain Metastases
  Pituitary Tumors
  Meningioma
  Vascular Malformations
  Trigeminal Neuralgia
  Movement Disorders and Obsessive Compulsive Disorder
  Glial Tumors
  Pediatric Tumors
  Section IV: Stereotactic Body Radiation Therapy Technique
  Physics of SBRT
  Immobilization
  Motion Management
  Charged Particle SBRT
  Section V: Stereotactic Body Radiation Therapy by Indication
  Primary Lung Cancers
  Lung Metastes
  Spinal Tumors
  Gastrointestinal Cancers
  Prostate Cancer
  Head and Neck Cancer
  Section VI: The Future of Radiosurgery and SBRT
  Patient Selection
  SRS and SBRT Complications and Management
  SRS AND SBRT Integration with Supportive Care
  Targeted Agents and Immunotherapy
  Diagnostic Imaging Advances
  Comparative Effectiveness.

  Digital Access Springer 2019
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• Article

  Genetic protein polymorphisms in human saliva: an interpretive review.

  Azen EA.

  Biochem Genet. 1978 Feb;16(1-2):79-99.

  The purpose of this review is to summarize recent progress in the field of genetic protein polymorphisms found in human saliva since 1972. Prior to 1972 most of the investigations were related to amylase. The genetics of salivary amylase will not be considered here, since it has recently been thoroughly reviewed elsewhere (Merritt and Karn, 1977). In this review, special attention will be devoted to the complex interrelationships of the proline-rich (Pr), double-band (Db), acidic protein (Pa), and peroxidase (SAPX) systems. The biochemically related Pr, Db, and Pa systems show distinctive genetic patterns, and there are associations between the phenotypes indicating linkage relationships. There is also evidence for probable interaction of products of the Pa and SAPX loci. Electrophoretic properties of these proteins can be defined in several gel systems, permitting an accurate definition of phenotypes. The usefulness and limitations of the different gel systems in the interpretation of these electrophoretic patterns will be illustrated. Allelic frequencies of the systems to be discussed are given in Table I. To aid comprehension, the systems will be discussed in logical rather than historical sequence.

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