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  • Book
    Wenxin Zheng, Oluwole Fadare, Charles Matthew Quick, Danhua Shen, Donghui Guo, editors.
    Summary: This fully indexed, 2-volume book covers all aspects of gynecologic and obstetric pathology. It focuses on practical issues in each chapter by demonstrating pitfalls of diagnosis in addition to general criteria needed for each disease entity. As a reference book on gynecologic and obstetric pathology, it is targeted for practicing pathologists, pathology residents, gynecologic pathology and oncology fellows, clinicians, healthcare providers, and biomedical researchers and is intended for use as a bench or scope side reference, resource for studying for board examinations or to satisfy any interest in certain topics within the field of gynecologic pathology. Volume 2 contains 17 chapters covering disease entities of the uterine myometrium, ovary, fallopian tube, peritoneum, placenta, gestational trophoblastic diseases, and gynecology related cytology. It covers all the recognized recent advances within the field. Key diagnostic and differential diagnosis related points are illustrated in numerous tables. In addition, plenty of high quality pictures are presented for the vast majority of entities to facilitate both learning and teaching.

    Contents:
    Lesions of fallopian tube
    Benign diseases of ovary
    Lesions of peritoneum and broad ligament
    Ovarian epithelial carcinogenesis
    Ovarian serous tumors
    Ovarian endometrioid and clear cell tumors
    Ovarian mucinous, transitional cell and other types of tumors
    Treatment principals for ovarian epithelial cancers
    Ovarian germ cell tumors
    Ovarian sex cord-stromal tumors
    Ovarian metastatic cancers
    Endometriosis
    Complications of early pregnancy and gestational trophoblastic diseases
    Gynecologic cytology
    Placenta pathology
    Pregnancy associated diseases
    Application of molecular biology in gynecologic pathology
    Application of immunohistochemistry in gynecologic pathology.
    Digital Access
    Provider
    Version
    Springer
    v. 1
    Springer
    v. 2
  • Article
    Alberto P.
    Antibiot Chemother (1971). 1978;23:88-98.
    Ara-C, a phase-specific antitumor agent, is rapidly deactivated by the enzyme cytidine deaminase. A prolongation of the biological activity of ara-C can be achieved either by the concomitant use of a cytidine deaminase inhibitor or by the development of ara-C derivatives with increased resistance to deamination and a longer half-life in serum. Among such derivatives are cyclocytidine (cyclo-C), anhydro-ara-5-fluorocytidine (AAFC) and the N4-acyl-derivatives. AAFC has been recently shown to be active in human leukemias and in solid tumors of the digestive tract. The tolerance to AAFC is sufficient for clinical use, and AAFC does not produce parotid pains and hypotension, characteristic side effects of cyclo-C. The main toxicity consists of myelodepression, nausea and vomiting. The schedule dependence of AAFC is far less pronounced than for ara-C, so that a weekly application by rapid i.v. injection of 30-40 mg/kg (1,200-1,500 mg/m2) reaches the level of activity with acceptable toxicity. AAFC seems to be as active as ara-C in acute leukemias and is probably active too in malignant lymphomas. In a large phase II trial of the EORTC on selected solid tumor types, AAFC showed a significant activity in GI tract adenocarcinomas with 2 responses/3 evaluable in pancreas, 7/14 in stomach and 2/32 in colorectal tumors (4/30). Hints of activity were also detected in breast cancer (1/17) and anaplastic small cell carcinoma of the lung (1/9). No responses were obtained in 27 patients with epidermoid carcinoma of the lung. These results confirm that ara-C, or newer ara-C analogs, are potentially active in various solid tumor types, and suggest that an extensive further clinical study of such new derivatives is warranted.
    Digital Access Access Options