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- BookXiaodong Liu, Guoyu Pan, editors.Contents:
Intro; Preface; Contents; Contributors;
Chapter 1: Overview: Role of Drug Transporters in Drug Disposition and Its Clinical Significance; 1.1 General Consideration; 1.2 Physiological Roles of Drug Transporters; 1.3 Roles of Drug Transporters in Inter-organ Communication; References;
Chapter 2: ABC Family Transporters; 2.1 Introduction; 2.1.1 General Properties of ABC Transporters; 2.1.2 Overview of Human ABC Gene Subfamilies; 2.1.2.1 ABCA Family; 2.1.2.2 ABCB Family; 2.1.2.3 ABCC Family; 2.1.2.4 ABCD Family; 2.1.2.5 ABCG Family; 2.2 P-Glycoprotein (P-GP/ABCB1) 2.2.1 General Properties and Distribution of P-GP2.2.2 Substrates and Inhibitors of P-GP; 2.2.3 Physiological and Pharmacological Functions of P-GP; 2.2.3.1 Function of P-GP at Blood-Brain Barrier; 2.2.3.2 Function of P-GP at Fetal-Maternal Barrier Function; 2.2.3.3 Function of P-GP at Hepatobiliary Excretion; 2.2.3.4 Function of P-GP in Restricting Oral Bioavailability of Drugs; 2.2.3.5 P-GP Function in the Kidney; 2.2.3.6 P-GP Function in Immune System; 2.2.4 Pharmacological Significance of P-GP Inhibition; 2.2.5 ABCB1 Polymorphisms and P-GP Expression/Function 2.3 Multidrug Resistance-Associated Proteins (MRPs/ABCCs)2.3.1 Multidrug Resistance-Associated Protein 1 (MRP1/ABCC1); 2.3.1.1 General Properties and Distribution of MRP1; 2.3.1.2 Substrates and Inhibitors of MRP1; 2.3.1.3 Pharmacological Functions of MRP1; 2.3.2 Multidrug Resistance Protein 2 (MRP2/ABCC2); 2.3.2.1 General Properties and Distribution of MRP2; 2.3.2.2 Substrates and Inhibitors of MRP2; 2.3.2.3 Pharmacological and Toxicological Functions of MRP2; 2.3.3 Multidrug Resistance Protein 3 (MRP3/ABCC3); 2.3.3.1 General Properties of MRP3 2.3.3.2 Pharmacological and Physiological Functions of MRP32.3.4 Multidrug Resistance Protein 4 (MRP4/ABCC4); 2.3.4.1 General Properties of MRP4; 2.3.4.2 Pharmacological and Physiological Function of MRP4; 2.3.5 Other Multidrug Resistance Proteins; 2.3.5.1 Multidrug Resistance Protein 5 (MRP5); 2.3.5.2 Multidrug Resistance Protein 6 (MRP6/ABCC6); 2.3.5.3 Multidrug Resistance Protein 7 (MRP7/ABCC10); 2.3.5.4 Multidrug Resistance Protein 8 (MRP8/ABCC11); 2.4 Breast Cancer Resistance Protein (BCRP/ABCG2); 2.4.1 General Properties and Distribution of BCRP; 2.4.2 Substrates and Inhibitors of BCRP 2.4.3 Pharmacological and Physiological Functions of BCRP2.4.3.1 Roles of BCRP in Disposition and Toxicity/Efficacy of Drugs; 2.4.3.2 BCRP and Side Population; 2.4.3.3 BCRP and Alzheimerś Disease; 2.4.3.4 BCRP and Hyperuricemia; 2.4.3.5 BCRP and Cancer; 2.5 ABC Genes and Human Genetic Disease; 2.5.1 Cystic Fibrosis and CFTR; 2.5.2 Adrenoleukodystrophy; 2.5.3 Sulfonylurea Receptor; 2.5.4 Bile Salt Transport Disorders; 2.5.5 Retinal Degeneration and ABCA4; 2.5.6 Mitochondrial Iron Homeostasis; 2.5.7 Sterol Transport Deficiencies; References;
Chapter 3: SLC Family Transporters 3.1 General IntroductionDigital Access Springer 2019 - ArticleModell JH.Annu Rev Med. 1978;29:1-8.The near-drowning victim must be treated immediately for ventilatory insufficiency, hypoxia, and the resulting acidosis. The cause and pathophysiologic changes of pulmonary insufficiency vary, depending on the tpe and volume of fluid aspirated. Success or failure of the overall resuscitative effort frequently depends on the adequacy of prompt emergency resuscitation and on effective intensive pulmonary care. Each patient should be evaluated and treated individually, since abnormalities of multiple organ systems can occur, their degree and form varying considerably from patient to patient (28).