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  • Book
    edited by Nils Hansson, Thorsten Halling, Heiner Fangerau.
    Summary: "Attributing Excellence in Medicine discusses the aura around the prestigious Nobel Prize in Physiology or Medicine. It analyzes the social processes and contingent factors leading to recognition and reputation in science and medicine. This volume will help the reader to better understand the dynamics of the attribution of excellence throughout the 20th century. Contributors are Massimiano Bucchi, Fabio De Sio, Jacalyn Duffin, Heiner Fangerau, Thorsten Halling, Nils Hansson, David S. Jones, Gustav Källstrand, Ulrich Koppitz, Pauline Mattsson, Katarina Nordqvist, Scott H. Podolsky, Thomas Schlich, and Sven Widmalm"-- Provided by publisher.

    Contents:
    Commemorating Excellence: The Nobel Prize and the Secular Religion of Science / Jacalyn Duffin
    More Than a Prize: The Creation of the Nobel System / Gustav Källstrand
    Hitler's Boycott: Cultural Politics and the Rhetoric of Neutrality / Sven Widmalm
    From Global Recognition to Global Health: Antimicrobials and the Nobel Prize, 1901-2015 / Scott H. Podolsky
    Discovery or Reputation? Jacques Loeb and the Role of Nomination
    Networks / Heiner Fangerau, Thorsten Halling and Nils Hansson
    Defining 'cutting-edge' Excellence: Awarding Nobel Prizes (or not) to Surgeons / Nils Hansson, David S. Jones and Thomas Schlich
    John C. Eccles' Conversion and the Meaning of 'Authority' / Fabio De Sio, Nils Hansson and Ulrich Koppitz
    The Laureate in the Spotlight: Renato Dulbecco and the Public Image of Science / Massimiano Bucchi
    Nobel Prize Awarded Discoveries and Commercialization: The Role of the Laureates / Katarina Nordqvist and Pauline Mattsson
    Digital Access 2019
    Access via Clio medica (Amsterdam, Netherlands) ; 2019; 98.
    Location
    Version
    Call Number
    Items
    Clio medica (Amsterdam, Netherlands) ; 2019; 98.
    2019
  • Article
    Williams RL, Trenholme GM, Carson PE, Frischer H, Rieckmann KH.
    Am J Trop Med Hyg. 1978 Mar;27(2 Pt 1):226-31.
    The disposition of sulfalene was studied in eight individuals before and during an infection with a chloroquine-resistant strain of Plasmodium falciparum. Isoniazid acetylator phenotype was determined in each individual prior to the administration of sulfalene. Following the administration of sulfalene before infection with malaria, a significant difference in half-life of non-acetylated sulfalene and percent acetylation of sulfalene in plasma was observed between rapid and slow acetylators. When sulfalene was administered during malaria, this difference was no longer apparent. Individuals who did not respond to the therapeutic administration of sulfalene alone were treated with a combination of sulfalene and pyrimethamine. Three individuals were cured by sulfalene without pyrimethamine and one was cured by the drug combination. Three of the four individuals who were not cured by any dose of sulfalene or the drug combination were slow acetylators. There was no distinct correlation between clinical response and maximum levels or half-life of nonacetylated sulfalene. These findings suggest that acetylator phenotype does not influence the therapeutic response of individuals infected with falciparum malaria to sulfalene or to the combination of sulfalene and pyrimethamine. Further information is presented, however, to confirm the importance of an as yet unidentified host factor(s) in determining therapeutic response to these agents.
    Digital Access Access Options