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  • Book
    [edited by] Marilyn Augustyn, MD, Professor of Pediatrics, Boston University School of Medicine, ... Show More Division Director, Developmental and Behavioral Pediatrics, Boston Medical Center, Boston, Massachusetts, Barry Zuckerman, MD, Professor and Chair Emeritus of Pediatrics, Boston University School of Medicine, Professor of Public Health, Boston University School of Public Health, Former Chair of Pediatrics, Boston Medical Center, Boston, Massachusetts.
    Summary: "Pediatricians are often the first line of defense for children with developmental and behavioral issues, and are often responsible for initial screening. This practical guide is geared toward primary care physicians to help them quickly identify issues and decide on next-steps. Chapters are in outline format, and cover a broad array of issues ranging from common childhood behavioral problems (biting, bullying, toilet training) to more critical (physical and sexual abuse, incarceration of a parent, violence). In addition, we have added more chapters addressing two generational approaches, because in our experience, the best way to help children is to help their parents and the best way to reach parents is through their children. Such chapters include parental depression, preventing unplanned pregnancy for parents of our patients, identifying and addressing social determinants of health, and parental self-understanding. We have also added new ideas to improve child health supervision for the 21st century specifically understanding and incorporating growth mindset, implicit bias, financial stress, cultural differences in parenting, and preventing unplanned pregnancy"-- Provided by publisher.
    Digital Access
    Provider
    Version
    Ovid
    2019
    LWW Health Library
    2019
  • Article
    Barclay BJ, Little JG.
    Mol Gen Genet. 1978 Mar 20;160(1):33-40.
    Thymidylate starvation in a yeast mutant auxotrophic for dTMP caused cell death and the induction of mutations in the mitochondrial genome. After 24 h of starvation almost all surviving cells were respiratory deficient petites. In addition, shorter episodes of dTMP starvation induced chloramphenicol and erythromycin resistant mutants, indicating the occurrence of mitochondrial point mutations. Suboptimal concentrations of exogenous thymidylate were also found to induce petites and a decline in cell viability and the magnitude of these effects was acutely dependent upon the dTMP concentration. Cesium chloride gradient analysis of DNA from cells undergoing thymineless incubation revealed a progressive loss of mitochondrial DNA, and a decrease in the molecular weight of nuclear DNA.
    Digital Access Access Options