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  • Book
    Helmut G. Rennke, Bradley M. Denker.
    Summary: "Renal pathophysiology can be a difficult subject even for the most advanced medical students. This Fifth Edition of Renal Pathophysiology: The Essentials provides an easy-to-read, case-based approach to learning the mechanisms of renal disease. Each chapter focuses on a mechanism of kidney disease and includes an opening case, learning objectives, integrated open-ended questions, and chapter-ending summaries. Updated with the latest clinical advances and research, this edition also features full-color illustrations and photomicrographs, suggested readings, and online and in-book Q&As"--Provided by publisher.

    Contents:
    Review of renal physiology
    Regulation of salt and water balance
    Disorders of water balance: hyponatremia, hypernatremia, polyuria
    Edematous conditions and the use of diuretics
    Acid-base physiology and metabolic alkalosis
    Metabolic acidosis
    Disorders of potassium balance
    Urinalysis and approach to the patient with renal disease
    Pathogenesis of major glomerular and vascular diseases
    Tubulointerstitial diseases
    Acute kidney injury
    Signs and symptoms of chronic renal failure
    Progression of chronic kidney disease
    Digital Access LWW Health Library (Medical Education) 2020
    Print
    Location
    Version
    Call Number
    Items
    Course Reserves: Request at Lane Information Desk
    2020
    RC903.9 .R49 2020
    1
  • Article
    Stock CC, Martin DS, Sugiura K, Fugmann RA, Mountain IM, Stockert E, Schmid FA, Tarnowski GS.
    J Surg Oncol. 1978;10(2):89-123.
    In a series of 6 experiments with CD8F1 mice with spontaneous mammary adenocarcinomas Sugiura noted by macrovisual observation with some histology an overall average of 21% of mice with lung metastases when treated with 1,000--2,000 mg/kg/day of amygdalin compared with 90% of the control mice. The significance attributed to those early observations is seriously challenged by the negative findings of 3 independent investigators, by 2 out of 3 negative cooperative experiments in which Sugiura participated, and particularly by the blind experiment in which he and others under blind readings found no anticancer activity. Treatment of Swiss albino mice showed no destructive effect upon their spontaneous mammary adenocarcinomas. Of the treated mice, 22% were found by macrovisual observation to have lung metastases while 91% were noted among the controls. The results are subject to questions raised in the discussion. Amygdalin at 2,000 mg/kg/day was ineffective both in treating and preventing the development of spontaneous leukemia in AKR mice. At 1,000 mg/kg/day it was not found effective in preventing or significantly delaying the development of spontaneous mammary tumors in CD8F1 mice. In summary, we do not have evidence to support taking amygdalin to clinical trial, although other considerations may require that one be conducted.
    Digital Access Access Options