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  • Book
    Peter Sutovsky, editor.
    Summary: This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C. elegans, bivalve molusc Mytilus and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five distinguished mitochondrial research teams from around the world, this volume will target a wide audience of physiologists, anatomists, cell, and developmental and evolutionary biologists, as well as physicians, veterinarians, livestock specialists and biomedical researchers.

    Contents:
    Chapter 1: Autophagosomal Sperm Organelle Clearance and mtDNA Inheritance in C. elegans
    Chapter 2: Doubly Uniparental Inheritance of mtDNA: an unappreciated defiance of a general rule
    Chapter 3: Exogenous factors may differentially influence the selective costs of mtDNA mutations
    Chapter 4: Dysfunctional Mitochondrial DNA Transmission and Its Implications for Mammalian Reproduction
    Chapter 5: Mitochondria Inspire a Lifestyle.
    Digital Access Springer 2019
  • Article
    Ward JI, Gorman G, Phillips C, Fraser DW.
    J Pediatr. 1978 May;92(5):713-7.
    Four episodes of serious Hemophilus influenzae type b infection occurred in three children attending a day-care center. This was 100 times the expected annual total. The pharyngeal carriage rate of Hib was 60% for siblings of patients, 20% for adult household contacts, and 5% for well children at the center. No carriers were found in control populations. Escherichia coli K100, which cross-reacts serologically with Hib, was found in rectal swabs of 20% of family contacts of patients and 3.5% of well children at the center. It was recovered from two of seven persons who carried Hib in the pharynx and two of 75 who did not (P = 0.035), suggesting that carriage of one organism may facilitate carriage of the other. In a randomized prospective trial with 85 patient contact, Hib carriage was eradicated in all of four carriers given ampicillin and in all of three given rifampin. There were no statistically significant differences in the rate of adverse reactions in the two treatment groups. No further cases were reported.
    Digital Access Access Options