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  • Book
    senior editors, Joel Bozue, Christopher K. Cote, Pamela J. Glass.
    Contents:
    Historical overview: from poisoned darts to pan-hazard preparedness
    Epidemiology of biowarfare and bioterrorism
    Food, waterborne, and agricultural diseases
    Consequence management: the local and national response
    Medical management of potential biological casualties: a stepwise approach
    Anthrax
    Brucellosis
    Glanders
    Melioidosis
    Plague
    Tularemia
    Q fever
    Multidrug-resistant bacterial infections as a threat to the US military health system: acinetobacter infections as a case study
    Botulinum toxin
    Clostridium perfringens epsilon toxin
    Ricin
    Staphylococcal enterotoxin B and related toxins produced by staphylococcus aureus and streptococcus pyogenes
    Toxins from venoms and poisons
    Marine algal toxins of concern as intentional contaminants
    Alphavirus encephalitides
    Hemorrhagic fever-causing mammarenaviruses
    Henipaviruses
    Filoviruses
    Smallpox and related orthopox viruses
    Emerging infectious diseases and future threats
    Laboratory identification of threats
    Medical countermeasures
    Future prospects of vaccines and antibodies in biodefense
    Aerobiology: history, development, and programs
    Biosafety
    Biological surety
    Ethical issues in the development of drugs and vaccines for biodefense
    Abbreviations and acronyms.
    Digital Access R2Library 2007
  • Article
    Pedersen OL.
    Eur J Clin Pharmacol. 1978 Mar 17;13(1):21-4.
    Verapamil was evaluated as an antihypertensive agent in a pilot study. Intravenous administration of 0.1 mg/kg, followed by constant infusion of 0.0035 mg/kg min, reduced both systolic and diastolic blood pressure significantly; the maximal average decrease of 23/16 mm Hg occurred after 5 min. The resting pulse rate rose during infusion and prolongation of the atrio-ventricular conduction time was a constant finding. After the initial drop in blood pressure, a rise toward control levels was observed, despite an increase in the infusion rate. Five patients received oral treatment with verapamil 320-640 mg daily for 7 weeks. In four of the five patients a blood pressure reduction was obtained (mean: 14/12 mm Hg), but normotension was not achieved in any of them. In contrast to the acute studies, the atrio-ventricular conduction time showed no change and a decrease in resting pulse rate was noted. Two patients experienced sensations of heat and reddening of face during treatment. It is concluded that verapamil has a rather modest antihypertensive effect and it is not suitable for the treatment of arterial hypertension.
    Digital Access Access Options