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  • Book
    Michael R. Pinsky, Jean-Louis Teboul, Jean-Louis Vincent, editors.
    Summary: This book, part of the European Society of Intensive Care Medicine textbook series, teaches readers how to use hemodynamic monitoring, an essential skill for today's intensivists. It offers a valuable guide for beginners, as well as for experienced intensivists who want to hone their skills, helping both groups detect an inadequacy of perfusion and make the right choices to achieve the main goal of hemodynamic monitoring in the critically ill, i.e., to correctly assess the cardiovascular system and its response to tissue oxygen demands. The book is divided into distinguished sections: from physiology to pathophysiology; clinical assessment and measurements; and clinical practice achievements including techniques, the basic goals in clinical practice as well as the more appropriate hemodynamic therapy to be applied in different conditions. All chapters use a learning-oriented style, with practical examples, key points and take home messages, helping readers quickly absorb the content and, at the same time, apply what they have learned in the clinical setting. The European Society of Intensive Care Medicine has developed the Lessons from the ICU series with the vision of providing focused and state-of-the-art overviews of central topics in Intensive Care and optimal resources for clinicians working in Intensive Care.

    Contents:
    Introduction (Jukka Takala)
    Part I. Physiology and Pathophysiology
    Chapter 1. Shock: definition and recognition (Massimo Antonelli)
    Chapter 2. Assessing the adequacy of cardiac output (Jean-Louis Vincent)
    Chapter 3. The determinants of Venous Return (Maurizio Cecconi)
    Chapter 4. Arterial blood Pressure Regulation (Michel Pinsky)
    Chapter 5. Pulmonary Circulation (Marco Maggiorini)
    Chapter 6. Heart Rate (Paul Marik)
    Chapter 7. Autonomic Dysfunction in Shock (Gareth Ackland)
    Chapter 8. Oxygen Delivery (Luciano Gattinoni)
    Chapter 9. Mitochondrial Function (Mervyn Singer)
    Chapter 10. Perioperative Hemodynamics (Andrew Rhodes)
    Chapter 11. Haemodynamics and Extracorporeal Circulation (Alain Combes)
    Part II. Clinical Assessment and Measurements
    Chapter 12. Clinical Assessment of Hemodynamic Instability (Jan Bakker)
    Chapter 13. Assessment of the microcirculation (Daniel De Backer)
    Chapter 14. SvO2/ScVO2 (Zsolt Molnar)
    ^Chapter 15. pcO2 gap (Ospina-Tascon)
    Chapter 16. Lactate (Glenn Hernandez)
    Part III. The Techniques
    Chapter 17. Cardiac Ultrasound Examination in Shock (Antoine Viellard Baron)
    Chapter 18. Non Cardiac Ultrasound Signs in Shock (Paul Mayo)
    Chapter 19. Central Venous Pressure (Sheldon Magder)
    Chapter 20. Arterial Blood Pressure (Jean-Louis Teboul)
    Chapter 21. Cardiac Output Monitors (Daniel Reuter)
    Chapter 22. Volumetric Monitoring (Manu Malbrain)
    Chapter 23. Assessment of Fluid Responsiveness (Xavier Monnet)
    Chapter 24. Pulmonary Arterial Catheter (Didier Payen)
    Chapter 25. Arterial Pressure Waveform Analysis Cardiac Output Monitoring (Ignacio Monge Garcia)
    Chapter 26. Oesophageal Doppler (Monty Mythen)
    Chapter 27. Bioimpedence / Bioreactance (Pierre Squara)
    Chapter 28. Other Techniques (Jacques Duranteau)
    Part IV. Basic Goals in Clinical Practice.-Chapter 29. Blood Pressure Targets in the initial stabilization (Pierre Asfar)
    ^Chapter 30. Choosing the right vasopressor (Anthony Gordon)
    Chapter 31. Fluid Resuscitation (Anders Perner)
    Part V. Choosing the Right Hemodynamic Therapy
    Chapter 32. In Acute Heart Failure (Alexandre Mebazaa)
    Chapter 33. In Septic Shock(Claude Martin)
    Chapter 34. In ARDS (Luciano Gattinoni)
    Chapter 35. In Neurological Emergencies (Fabio Taccone)
    Chapter 36. For Perioperative Optimisation (Rupert Pearse)
    Chapter 37. In a Patient under ECMO (Richard Beale). .
    Digital Access Springer 2019
  • Article
    Hynes RO, Ali IU, Mautner VM, Destree A.
    Birth Defects Orig Artic Ser. 1978;14(2):139-53.
    LETS is a large surface glycoprotein that is found on normal fibroblasts, but is absent or exists in amounts on transformed cells. Immunofluorescent staining shows LETS protein fibrils arrayed around the cells, particularly concentrated beneath the cells and in the area between neighboring cells. LETS glycoprotein is disulfide-bonded at the cell surface into dimers and higher aggregates. Other surface proteins also appear to participate in disulfide bonding. Reduction of disulfide bonds leads to increased release of LETS protein from the cells, as does the addition of cytochalasin B. Purified LETS protein added to transformed cells binds to the cells in a fibrillar array similar to that seen on normal cells. Addition of LETS protein leads to increased attachment and spreading of cells and causes transformed cells to align like normal ones. It also causes the appearance of actin cables in transformed cells, which normally lack them. These effects are inhibited by specific antisera to LETS protein or by reduction of disulfide bonds in the protein and are blocked or reversed by proteolysis. The results suggest that LETS protein plays a role in adhesion of cells.
    Digital Access Access Options