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  • Book
    Jordi Rimola, editor.
    Summary: This book comprehensively describes the state of the art in cross-sectional imaging of Crohn's disease from both a clinical and a radiological perspective. The uses and impact of the different imaging techniques in daily practice and research are thoroughly examined, with coverage of ultrasound, computed tomography and magnetic resonance. In addition, emerging trends are scrutinized. The background to the book is an increasing perception that intestinal inflammation and complications are underdiagnosed using standard endoscopic or surgical techniques. Patients with Crohn's disease usually require multiple reassessments during their lifetimes and often favor noninvasive techniques with a low risk of complications. These factors have reinforced the need for effective cross-sectional imaging techniques. Additionally, the expanding use of biologic agents, combined with their increased efficacy, expense, and risk, justifies the use of these techniques (particularly ultrasound and magnetic resonance) to monitor disease treatment and objectively measure inflammation and healing. Cross-Sectional Imaging in Crohn's Disease will be of high value for both gastroenterologists and diagnostic radiologists.
    Digital Access Springer 2019
  • Article
    Breitenfield RV, Pachucki LC, Hebert LA, Piering WF, Lemann J.
    Arch Intern Med. 1978 Apr;138(4):583-5.
    Change in peripheral blood WBC and differential cell count in response to oral glucocorticoids (steroids) was examined in 36 stable renal transplant patients receiving their usual steroid dose on a daily or alternate-day steroid schedule. Three hours following steroid therapy mean WBC count had increased significantly. Mean change in WBC count was +2,400 cells/cu mm with individual values ranging from -600 to +8,000/cu mm. No differences were observed between patients receiving daily or alternate-day regimens. Changes in WBC count were due almost entirely to an increase in segmented granulocytes and a decrease in lymphocytes. there was no correlation between dose of steroid and WBC responses. However, when retested, a given patient's WBC response to a given dose of steroid was reproducible. Differences between patients, with respect to WBC response to steroids, could not be explained by differences in azathioprine dose and was not related to initial WBC count hematocrit value, age, duration of transplant, or levels of serum creatinine, BUM, or serum phosphorus. Because of the clinical importance of the WBC count in the renal transplant recipient and the potential for large and unpredictable changes in WBC count in response to steroids, WBC and differential cell count should be obtained before the morning steroid dose.
    Digital Access Access Options