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  • Book
    Rachel L. Richesson, James E. Andrews, editors.
    Summary: This extensively revised new edition comprehensively reviews the rise of clinical research informatics (CRI). It enables the reader to develop a thorough understanding of how CRI has developed and the evolving challenges facing the biomedical informatician in the modern clinical research environment. Emphasis is placed on the changing role of the consumer, and the need to merge clinical care delivery and research as part of a changing paradigm in global healthcare delivery. Clinical Research Informatics presents a detailed review of using informatics in the continually evolving clinical research environment. It represents a valuable textbook reference for all students and practising healthcare informaticians looking to learn and expand their understanding of this fast-moving and increasingly important discipline.

    Contents:
    Introduction
    Section I: Contexts of Clinical Research Informatics
    From Notations to Data: The Digital Transformation of Clinical Research
    The Clinical Research Environment
    Methodological Foundations of Clinical Research
    Informatics Approaches to Participant Recruitment
    The Evolving Role of Consumers
    Clinical Research in the Post-genomic Era
    Section II: Data Management and Systems in Clinical Research
    Clinical Research Information Systems
    Study Protocol Representation
    Data Quality in Clinical Research
    Patient-Reported Outcome Data
    Biobanking Challenges and Informatics Opportunities
    Laboratory Data
    Patient Registries
    Knowledge Representation and Discovery
    Section III: Knowledge Representation and Ontologies
    Non hypothesis-driven Research: Data Mining and Knowledge Discovery
    Natural Language Processing, Electronic Health Records, and Clinical Research
    The Future of Clinical Research, Health, and Clinical Research Informatics
    Data Governance
    Data Sharing: Electronic Health Records and Research Interoperability
    Standards Development and the Future of Research Data Sources, Interoperability, and Exchange
    Pharmacovigilance
    Clinical Trials Registries and Results Databases
    Future Directions in Clinical Research Informatics.
    Digital Access Springer 2019
  • Article
    Anderson DE.
    Semin Oncol. 1978 Mar;5(1):11-6.
    From this brief review is should be evident that the hereditary varieties of common cancers are characterized by a high degree of genetic heterogeneity. The specific types of hereditary cancers can be identified by focusing on the histologic types and sites of involvement, not only of the primary neoplasm, but also of associated neoplasms and associated conditions or stigmata, as well as by focusing on the age of the patient at the time of diagnosis, tumor localization and frequency, and the mode of inheritance. Identification of specific types of hereditary cancers has important utility as a means of isolating homogeneous groups of patients and unaffected relatives for studies aimed at elucidating the mechanisms of carcinogenesis.
    Digital Access Access Options