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  • Book
    Nicholas S. Ward, Mitchell M. Levy, editors.
    Summary: This book is designed to provide a comprehensive and state-of-the-art resource for clinicians who care for patients with sepsis and research scientist alike, . Patients with severe sepsis requiring ICU admission have very high rates of ICU and overall hospital mortality, with estimates ranging from 18 to 50%. Risk factors for death from sepsis include underlying illness, increased age, and multi-system organ failure. This is compounded by the significant variation in the management of early severe sepsis. Care of these patients and clinical conditions can be quite complex, and materials are collected from the most current, evidence-based resources. Book sections have been structured to review the overall definitions and epidemiology of sepsis as well as current insights into the pathophysiology of sepsis. This review summarizes the evidence for the international consensus guidelines for the identification and management of sepsis. The latter part of this book reviews emerging concepts and approaches in the diagnosis and management of sepsis that may significantly reduce mortality in the future. Sepsis: Pathophysiology, Definitions and the Challenge of Bedside Management represents a collaboration between authors drawn from a variety of disciplines and contributions from basic scientists and highly recognized clinical opinion leaders with expertise in clinical trials.

    Contents:
    Section 1
    Chapter 1 Introduction
    Chapter 2 Sepsis Definitions
    Chapter 3 Epidemiology of Sepsis: Current Data and Predictions for the Future
    Section 2
    Chapter 4 Overview of the Molecular Pathways and Mediators of Sepsis
    Chapter 5 Sepsis-induced Immune Suppression
    Chapter 6 Molecular Targets for Therapy
    Section 3
    Chapter 7 Mechanisms of Organ Dysfunction in Sepsis
    Chapter 8 Sepsis-Induced AKI
    Chapter 9 Sepsis and the Lung
    Chapter 10 Organ Dysfunction in Sepsis: Brain, Neuromuscular, Cardiovascular, and Gastrointestinal
    Section 4
    Chapter 11 Diagnosis of Sepsis: Clinical Findings and the Role of Biomarkers
    Chapter 12 Source Control in Sepsis
    Chapter 13 Hemodynamic Support in Sepsis
    Chapter 14 Bundled Therapies in Sepsis
    Chapter 15 Genetics in the Prevention and Treatment of Sepsis.
    Digital Access Springer 2017
  • Article
    Lehle L, Tanner W.
    Biochim Biophys Acta. 1978 Mar 01;539(2):218-29.
    Yeast membranes incorporate radioactivity from GDP[14C]mannose into various glycolipids. These can be separated by thin layer chromatography into at least seven components. The major component has been identified previously as dolichyl monophosphate mannose. Only one additional component is not sensitive to mild alkaline saponification, but is hydrolyzed instead under mild acidic conditions. This latter glycolipid has all the characteristics of a polyprenyl diphosphate oligosaccharide with a sugar moiety of more than 12 hexose units. It runs like dolichyl diphosphate derivatives on a DEAE column and evidence is presented that the lipid moiety is a polyprenol. When radioactive Dol-PP-di-N-acetylchitobiose is incubated with yeast membranes in the presence of non-radioactive GDPmannose a small amount of a larger lipid oligosaccharides is formed besides the previously-described Dol-PP-(GlcNAc)2 mannose. This oligosaccharide has all the properties of the glycolipid described above. Its formation is greatly increased when Triton is omitted from the incubation. Radioactivity of the polyprenyl diphosphate [14C]oligosaccharide is transferred to ethanol-insoluble material, most likely endogenous membrane glycoproteins.
    Digital Access Access Options