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- BookBarbara Fadem, Ph.D., Professor, Department of Psychiatry, Rutgers New Jersey Medical School, Newark, New Jersey.Contents:
The beginning of life: pregnancy through preschool
School age, adolescence, special issues of development, and adulthood
Aging, death, and bereavement
Genetics, anatomy, and biochemistry of behavior
Biological assessment of patients with psychiatric symptoms
Psychoanalytic theory and defense mechanisms
Learning theory
Clinical assessment of patients with behavioral symptoms
Substance-related disorders
Normal sleep and sleep disorders
Schizophrenia spectrum and other psychotic disorders
Depressive disorders and bipolar and related disorders
Anxiety disorders, somatic disorders, and related conditions
Neurocognitive, personality, dissociative, and eating disorders
Psychiatric disorders in children
Biologic therapies: psychopharmacology
Psychological therapies
The family, culture, and illness
Sexuality
Aggression and abuse
The physician-patient relationship
Psychosomatic medicine
Legal and ethical issues in medicine
Health care in the United States
Medical epidemiology
Statistical analyses. - ArticleWaldron C, Jund R, Lacroute F.Biochem J. 1977 Dec 15;168(3):409-15.From the protein and RNA content of Saccharomyces cerevisiae growing in different media we calculate that ribosome efficiency is changed: incorporation of amino acids into protein decreases from 8.8 amino acids/s per ribosome in fast-growing cells (0.54 doubling/h) to 5.2 amino acids/s per ribosome in slow-growing cells (0.30 doubling/h). We could not detect significant protein turnover in either fast-or slow-growing cultures, so the lower ribosome efficiency does not seem to be an artifact caused by changes in unstable protein production at different growth rates. Nor is the lower ribosome efficiency due to slower migration of ribosomes along mRNA: the times required to complete polypeptides of known molecular weights are the same in slow-growing cells as those previously determined for fast-growing cells [Waldron, Jund & Lacroute (1974) FEBS Lett. 46, 11-16]. We therefore deduce that ribosome efficiency changes in yeast because the fraction of ribosomes engaged in protein synthesis falls (from 84% in fast-growing cells to 50% in slow-growing cells.