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  • Book
    John Beynon, Dean Anthony Harris, Mark Davies, Martyn Evans, editors.
    Summary: The topics covered in this book have been specifically chosen to give guidance to surgeons established in practice and those embarking on their careers. Examples include the changing management in the treatment of the catastrophic abdominal wall, perianal Crohn's disease in the biological era, decision making in rectal cancer that responds to radiotherapy, and the assessment of outcomes in colorectal cancer surgery. Recent years have seen the introduction of technical advances with respect to robotics in colorectal surgery and trans-anal total meso-rectal excision, and which are rapidly becoming established in clinical practice. Chapters also cover those aspects of colorectal practice, which are common to all, and provide guidance on management of topics including complications of radiotherapy, management of pouch dysfunction and iatrogenic complications in pelvic cancer surgery.

    Contents:
    1. Management of perianal Crohn's disease in the biologic era
    2. The Catastrophic Abdominal Wall
    3. Colorectal Complications of Radiotherapy
    4. Robotics in Colorectal Surgery
    5. The Dysfunctional Pouch
    6. The iatrogenic complications of pelvic cancer surgery
    7. Assessment of bowel vascularity and adjuncts to anastomotic healing
    8. Transanal Total Mesorectal Excision
    9. Anal cancer and sentinel node biopsy
    10. Rectal Cancer that responds to radiotherapy
    11. The advanced primary or recurrent rectal cancer: pushing the boundaries
    12. Personalized genomics and molecular profiles in colorectal cancer: towards precision cancer care
    13. Assessing outcomes in colorectal cancer surgery.
    Digital Access Springer 2017
  • Article
    Schwarzstein L, Aparicio NJ, Turner D, de Turner EA, Schally AV, Coy DH.
    Andrologia. 1978 Jan-Feb;10(1):59-65.
    The LH, FSH and testosterone response to 50 microgram i.v. LH-RH and to 2.5, 5.0, 10.0, and 20.0 microgram i.m. D-Leu-6-LH-RH-ethylamide was studied in 6 subjects with normogonadotrophic, idiopathic oligozoospermia. All injections were given between 8:00 and 9:00 a.m. at weekly intervals. Blood samples were collected before and 30 and 45 minutes after injection of LH-RH, and before and 2, 4, 6, 12, and 24 hours after D-Leu-6-LH-RH-ethylamide injections. Serum levels of LH, FSH, and testosterone were measured by triplicate by R.I.A. LH and FSH responses to LH-RH showed peak values at 30 minutes, whereas following injections of D-Leu-6-LH-RH-ethylamide, maximal values were recorded between 4 and 6 hours and were higher than those obtained with LH-RH. A significant rise of serum testosterone levels was observed after all stimuli, with peak values 45 minutes after LH-RH and 4 to 6 hours after D-Leu-6-Lh-RH-ethylamide injections. The testosterone levels obtained following LH-RH and different doses of the analogue did not differ significantly from one another. The same sequence of maximal LH and FSH values was obtained after injections of LH-RH and of D-Leu-6-LH-RH-ethylamide, particularly at doses of 10.0 and 20.0 microgram. This suggests that the gonadotrophin response to these agents would be a true reflection of the individual mode of pituitary response.
    Digital Access Access Options