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- ArticleMcCredie J, Loewenthal J.Am J Surg. 1978 Mar;135(3):293-7.An hypothesis of neural crest injury, derived from a radiologic analysis of thalidomide deformities, is suggested as a possible pathogenetic mechanism of dysmelia and its associated visceral defects. Supportive evidence from a variety of sources is presented, and the hypothesis is shown to provide a unifying concept for a number of previously unrelated facts.