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  • Book
    Christopher W. Mastropietro, Kevin M. Valentine, editors.
    Contents:
    Important Topics for Further DiscussionFuture Directions; References;
    2: Extracorporeal Membrane Oxygenation for Acute Pediatric Respiratory Failure; Introduction; Indications for ECMO; Hypoxemic Respiratory Failure and Pediatric Acute Respiratory Distress Syndrome; Hypercarbic Respiratory Failure; Airway Disorders; Patient Selection; Diagnosis; Duration of Mechanical Ventilation; Patient Comorbidities; ECMO Modality and Cannulation Strategy; Pulmonary Management; Ventilator Management; Secretion Clearance on ECMO; Extubation on ECMO; Recommendations Centralization of ECMO and the Effect of Center VolumeProlonged ECMO and Lung Transplantation; Long-Term ECMO; ECMO as a Bridge to Lung Transplant; Considerations on Prolonged ECMO; Termination of Extracorporeal Support; Conclusion; References;
    3: Weaning and Extubation Readiness Assessment in Pediatric Patients; Introduction; Definitions; Ventilator Weaning Versus Extubation Readiness; Extubation Failure; Post-Extubation Stridor and Upper Airway Obstruction; Ventilator Weaning; Causes of Ventilator Weaning Failure; Respiratory Muscle Weakness; Cardiac Dysfunction and Pulmonary Hypertension Fluid OverloadSedation Optimization; Mucociliary Clearance; Extubation Readiness Assessment in Pediatric ICU; Screening for Entry Criteria into the ERT; Respiratory Support during the ERT; Duration of the ERT; Criteria for What Constitutes a Successful ERT; Anticipation of Post-Extubation Respiratory Support; Establishing a Respiratory Therapist-Driven Extubation Readiness Assessment Protocol; Potential Adjuncts to Extubation Readiness Assessment; Extubation Failure; Strategies to Prevent Post-Extubation Upper Airway Obstruction; Extubation in Special Patient Populations Intro; Foreword; Preface; Contents; List of Contributors; Part I: Respiratory Controversies;
    1: Ventilator Management for Pediatric Acute Respiratory Distress Syndrome; Pathogenesis of Acute Respiratory Distress Syndrome; Definition of Pediatric ARDS; Noninvasive Respiratory Support; Lung-Protective Strategies; Tidal Volume Delivery: Volutrauma; PEEP Titration: Atelectrauma; Plateau Pressure and Drive Pressure (ΔP): Barotrauma; High-Frequency Oscillatory Ventilation; Adjunctive Therapies; Recruitment Maneuvers; Prone Positioning; Inhaled Nitric Oxide; Surfactant Congenital or Acquired Cardiac DiseaseTraumatic Brain Injury; Neuromuscular Disease; Patient with Chronic Respiratory Support; Future Directions; References;
    4: Management of Status Asthmaticus in Critically Ill Children; Introduction; Pathophysiology: A Brief Précis; Clinical Assessment; Diagnostic Evaluation; Fiberoptic Bronchoscopy; Xenon Ventilation Computed Tomography; Exhaled Nitric Oxide; Pharmacological Management; Inhaled β-Adrenergic Agonists; Anticholinergic Agents; Anti-inflammatory Drugs; Magnesium; Methylxanthine Drugs; Intravenous Albuterol; Intravenous Terbutaline
    Digital Access Springer 2018
  • Article
    Turner AS, Watson OF, Brocklehurst JE.
    N Z Med J. 1977 Sep 28;86(596):286-9.
    The events after the first dose of prazosin have been studied. Twenty-four patients with hypertension were given a single 1 mg tablet. Supine and erect blood pressures were recorded at 15-minute intervals for up to 270 minutes. Six had no previous therapy, 18 were uncontrolled on other drugs, chiefly thiazides or beta-adrenergic blockers or a combination of both. In 10 patients in whom no symptoms of postural hypotension occurred, there was a mean maximum erect diastolic blood pressure fall of 21/14mmHg at an average of 110 minutes after the dose. The remaining 14 had symptoms of postural hypotension of which four were milk, seven moderate and three severe. The mean maximum erect diastolic blood pressure reduction in this group was 67/52mmHg at a mean of 90 minutes after the dose. Subsequent therapeutic response was better in those with an abrupt initial blood pressure fall. Twenty-two further patients were studied in the same manner with a single dose 0.5mg (tablet), 11 of them in a double-blind within-patient crossover study with placebo. Postural symptoms or significant tachycardia did not occur with this dose. Most patients experience some postural hypotension after the first dose of prazosin. Symptoms occur only when this fall is marked, and the extent of the fall is dose related.
    Digital Access Access Options