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  • Book
    Martin W. Dünser, Daniel Dankl, Sirak Petros, Mervyn Mer, editors.
    Summary: This well-illustrated book provides detailed guidance on all aspects of physical examination in patients requiring emergency or intensive care. After an introductory section covering basic principles and the recognition of pre-terminal signs, the approach to examination of individual organ systems is clearly explained. Examination schemes are then presented for particular conditions or settings, including respiratory distress, shock, neurological disease, trauma, suspected infection, and cardiac arrest. The skill of physical examination has become the forgotten art of medicine in both undergraduate and postgraduate studies. Furthermore, most books on the topic have so far focused on examination practices applicable to non-critically ill patients. In emergency and intensive care medicine, however, a different approach and sometimes also different examination techniques are required due to the life-threatening disease process. In summarizing knowledge and providing guidance on physical examination in this specific subgroup of patients, this book will meet the needs of all physicians and allied health care professionals involved in the care of critically ill patients.
    Digital Access Springer 2018
  • Article
    Seprodi J, Coy DH, Vilchez-Martinez JA, Pedroza E, Schally AV.
    J Med Chem. 1978 Mar;21(3):276-80.
    Benzoyl-, acetylsalicylyl-, indomethacinyl-, pyroglutamylhistidyl-, and pyroglutamyl-D-phenylalanyl-D-tryptophanylseryltyrosyl groups were attached to a moderately active inhibitory analogue of LH-RH, [D-Phe2,D-Trp3-D-Lys6]-LH-RH, via the epsilon-amino group of the lysine residue. The resulting compounds were assayed for anti-LH-RH activity and for their ability to block ovulation in the rat. The decrease in polarity and increase in size of the lysine side chain resulting from addition of the aromatic acyl groups gave almost no increase in inhibitory activity. Addition of the dipeptide, less than Glu-His, also had little effect on potency. However, incorporation of the pentapeptide sequence to give a branched pentadecapeptide with essentially two N termini resulted in antiovulatory activity greater than the parent peptide or any other analogue thus far tested by us. The corresponding agonist peptide, [Nepsilon-(less than Glu-His-Trp-Ser-Tyr)-D-Lys6]-LH-RH, was also synthesized and tested for LH- and FSH-releasing activity. Surprisingly, it was no more active than [D-Lys6]-LH-RH itself, suggesting that an intact C terminus as well as an N terminus is necessary for the full expression of gonadotropin release.
    Digital Access Access Options