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  • Book
    Brit Long, Alex Koyfman, editors.
    Summary: This book provides emergency physicians with an easy-to-use guide for diagnosing and treating ophthalmologic conditions in the emergency department. Ophthalmologic complaints are very common, but many emergency physicians are not as confident as they would like to be when evaluating and managing these conditions. This book answers that need by giving step-by-step instructions on how to diagnose and treat common eye conditions, including glaucoma, infections, neuro-ophthalmologic conditions, and trauma. For each disorder, the book discusses presentation/symptoms, physical examination techniques, lab and imaging findings, differential diagnoses, treatment guidelines, and referral suggestions. The text is filled with images that clearly present these common ophthalmologic complaints and conditions and guide the emergency physician to an accurate and swift diagnosis. Handbook of Emergency Ophthalmology is an essential resource for emergency physicians, residents, medical students, nurses, and other healthcare workers who evaluate and manage patients with ophthalmologic conditions.
    Digital Access Springer 2018
  • Article
    Kosher RA.
    J Exp Zool. 1978 Feb;203(2):215-22.
    The present study represents a first step in investigating the possible involvement of calcium (Ca2+) in the stimulation of somite chondrogenesis elicited by extracellular matrix components produced by the embryonic notochord. The ionophore, A23187, a drug that facilitates Ca2+ uptake leading to elevation of cytoplasmic Ca2+ levels, at concentrations of 0.25-1.0 microgram/ml severely impairs "spontaneous" somite chondrogenesis, i.e., inhibits the formation of the small amount of cartilaginous matrix normally formed by embryonic somites in vitro in the absence of inducing tissues. This inhibition is reflected in a considerable reduction in sulfated glycosaminoglycan (GAG) accumulation by A23187-treated somite explants. Furthermore, A23187 inhibits the striking stimulation of cartilaginous matrix formation and sulfated GAG accumulation normally elicited by the embryonic notochord and collagen substrates. In fact, 1.0 microgram/ml of A23187 reduces sulfated GAG accumulation by somites cultured in association with notochord or on collagen to a level even below that accumulated by somites cultured in the absence of these inductive agents. Although these results must be interpreted with caution, they provide incentive for considering a possible regulatory role for Ca2+ in the chondrogenic response of somites to extracellular matrix components produced by the embryonic notochord.
    Digital Access Access Options