Today's Hours: 8:00am - 10:00pm
Lane Medical Library

Search

Filter Results

Did You Mean:

Search Results

Sort by
relevance
  • Book
    by Yasser M. Awaad.
    Summary: This practical book features more than 1000 questions and answers with illustrations for pediatric neurologists, adult neurologists, general pediatricians and students taking their initial board examination and maintenance of certification. All questions are in multiple choice format and followed by the correct answer with a full explanation and appropriate references. Chapters are sectioned by different topics in pediatric neurology, including Epilepsy, Metabolic Disorders and Movement Disorders and other topics. Timely and thorough, this is a handy and succinct resource.

    Contents:
    Autism
    Behavior Disorders
    Congenital & Genetic Disorders
    Demyelinating Disorders
    Eating Disorders
    Epilepsy
    Ethics and Professionalism
    Neurodegenerative Disorders
    Neuro-metabolic Disorders
    Headache
    Developmental Disorders
    Infections
    Mental Retardation
    Movement Disorders
    Neurological complications of Systemic Diseases
    Neuromuscular Disorders
    Neuro-Oncology
    Neuro-Ophthalmology
    Neurophysiology
    Sleep Disorders
    Spinal Cord Disorders
    Static encephalopathy/cerebral palsy/rehabilitation
    Toxic Encephalopathy
    Traumatic Brain Injury
    Vascular.
    Digital Access Springer 2018
  • Article
    Kimura H, Futai M.
    J Biol Chem. 1978 Feb 25;253(4):1095-110.
    Membrane-bound L-lactate dehydrogenase was freed from the detergent used during purification. The detergent-free enzyme had about one-half the specific activity of the enzyme in 1.0% Tween 80, and was only partially sensitive to the specific antibody. This enzyme was activated about 3-fold with phosphatidylglycerol, cardiolipin, or a mixture of phospholipids. The phospholipid-activated enzyme had a similar Km value for L-lactate to that of the membrane enzyme and was completely inhibited by the specific antibody. On heat treatment, the phospholipid-activated enzyme was more stable than detergent-free enzyme and was as stable as membrane-bound enzyme. The alpha helical content of the enzyme increased 1.7-fold during preincubation with these lipids and the alpha helix became more stable during heat treatment than that of the detergent-free enzyme. These results suggest that the enzyme showed monomolecular dispersion in the lipid bilayer and that its conformation, including its active site and secondary structure, was different from that of the detergent-free enzyme. Phosphatidylethanolamine, dilauroyl lecithin and lecithin from egg yolk had none of the above effects on the activity or the secondary structure of the enzyme. On the other hand, mixtures of each of these lipids and cholate had essentially similar effects to phosphatidylglycerol.
    Digital Access Access Options