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  • Book
    Giorgio Pajardi, Marie A. Badalamente, Lawrence C. Hurst, editors.
    Summary: This book offers detailed guidance on the use of collagenase, or enzymatic fasciotomy, as a nonsurgical treatment for Dupuytren's contracture and explains its role in relation to the other forms of treatment, including open fasciectomy, needle aponeurotomy, and lipofilling. Clear guidance is provided on technique, current indications, and off-label usage. With the help of tips and tricks from leading experts, the reader will learn how to personalize the procedure to meet the needs of individual patients. Advice is also provided on all aspects of rehabilitation, which is a key determinant of treatment outcome. Collagenase treatment of Dupuytren's disease has the benefits of low invasiveness and rapid patient recovery and achieves reasonable recurrence-free periods. It is especially valuable in patients with rapid recurrence following surgery. In documenting and appraising every aspect of its use, this book will be of value for all who treat patients with Dupuytren's disease, including hand surgeons, orthopedists, plastic surgeons, physiatrists, and physiotherapists.

    Contents:
    1 Biochemistry and mechanism of action of collagen
    2 Pre-Clinical evaluation and early clinical trials in USA
    3 Dupuytren's Disease: topographic anatomy of lesions
    4 Experimental phase in Europe: protocol and first results
    5 Preparation, injection and traction procedures (Pearls and Tips & Tricks): technical evolution
    6 First web space, thumb, and nodules
    7 Rehabilitation after treatment
    8 Collagenase today: follow-up studies, recurrence, dosage, drug safety
    9 American and European Regulations
    10 Collagenase: future perspectives. .
    Digital Access Springer 2018
  • Article
    Webb RB.
    J Bacteriol. 1978 Feb;133(2):860-6.
    Reversion to tryptophan independence induced by 365-nm and 254-nm radiation was studied in Escherichia coli WP2s (B/r trp uvrA). Under aerobic conditions, the mutant frequency responses was of the fluence-square or "two-hit" type at both 365 and 254 nm when revertants were assayed on minimal agar supplemented with 2% nutrient broth (SEM plates). In contrast, when mutants were assayed on minimal agar supplemented with tryptophan only, the revertant yield was reduced to very low values at 365 nm, whereas values substantially greater than with SEM plates were obtained at 254 nm. Premutational lesions induced by both 365-nm and 254-nm radiation were photoreactivated more than 10-fold when assayed on SEM plates, implicating pyrimidine dimers as premutational lesions at both wavelengths. The strong photoreactivation of 365-nm-induced mutagenesis contrasted strikingly with the complete absence of photoreactivation of 365-nm-induced lethality in this strain.
    Digital Access Access Options