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  • Book
    Cheng Dong, Nastaran Zahir, Konstantinos Konstantopoulos, editors.
    Summary: "This book covers multi-scale biomechanics for oncology, ranging from cells and tissues to whole organ. Topics covered include, but not limited to, biomaterials in mechano-oncology, non-invasive imaging techniques, mechanical models of cell migration, cancer cell mechanics, and platelet-based drug delivery for cancer applications. This is an ideal book for graduate students, biomedical engineers, and researchers in the field of mechanobiology and oncology"--Publisher's description.

    Contents:
    The National Cancer Institute investment in biomechanics in oncology research / Anthony Dickherber, Shannon K. Hughes, Nastaran Zahir
    DNA mechanics and topology / Sumitabha Brahmachari, John F. Marko
    Mechanics of the cell nucleus / Dong-Hwee Kim, Jungwon Hah, Denis Wirtz
    Extracellular matrix stiffness exists in a feedback loop that drives tumor progression / Allison K. Simi, Mei-Fong Pang, Celeste M. Nelson
    Microenvironment influences cancer cell mechanics from tumor growth to metastasis / Deepraj Ghosh, Michelle R. Dawson
    Mechanical forces in tumor angiogenesis / Matthew R. Zanotelli, Cynthia A. Reinhart-King
    From cancer immunoediting to new strategies in cancer immunotherapy: the roles of immune cells and mechanics in oncology / Virginia Aragon-Sanabria, Gloria B. Kim, Cheng Dong
    Exposing cell-itary confinement: understanding the mechanisms of confined single cell migration / Bin Sheng Wong, Panagiotis Mistriotis, Konstantinos Konstantopoulos
    Modeling cell migration mechanics / Louis S. Prahl, David J. Odde
    Engineered models of metastasis with application to study cancer biomechanics / Michelle B. Chen, Roger D. Kamm, Emad Moeendarbary
    Biomechanics of the circulating tumor cell microenvironment / Benjamin L. Krog, Michael D. Henry
    Platelet-based drug delivery for cancer applications / Nerymar Ortiz-Otero, Zeinab Mohamed, Michael R. King
    Biomaterials in mechano-oncology: means to tune materials to study cancer / Shelly R. Peyton, Maria F. Gencoglu, Sualyneth Galarza, Alyssa D. Schwartz
    Design of fiber networks for studying metastatic invasion / Apratim Mukherjee, Aniket Jana, Brian Koons, Amrinder Nain
    Traction force microscopy for noninvasive imaging of cell forces / Jeffrey A. Mulligan, François Bordeleau, Cynthia A. Reinhart-King, Steven G. Adie
    Noninvasive imaging: Brillouin confocal microscopy / Miloš Nikolić, Christina Conrad, Jitao Zhang, Giuliano Scarcelli.
    Digital Access Springer 2018
  • Article
    Friedrich B, Magasanik B.
    J Bacteriol. 1978 Feb;133(2):680-5.
    Klebsiella aerogenes utilized arginine as the sole source of carbon or nitrogen for growth. Arginine was degraded to 2-ketoglutarate and not to succinate, since a citrate synthaseless mutant grows on arginine as the only nitrogen source. When glucose was the energy source, all four nitrogen atoms of arginine were utilized. Three of them apparently did not pass through ammonia but were transferred by transamination, since a mutant unable to produce glutamate by glutamate synthase or glutamate dehydrogenase utilized three of four nitrogen atoms of arginine. Urea was not involved as intermediate, since a unreaseless mutant did not accumulate urea and grew on arginine as efficiently as the wild-type strain. Ornithine appeared to be an intermediate, because cells grown either on glucose and arginine or arginine alone could convert arginine in the presence of hydroxylamine to ornithine. This indicates that an amidinotransferase is the initiating enzyme of arginine breakdown. In addition, the cells contained a transaminase specific for ornithine. In contrast to the hydroxylamine-dependent reaction, this activity could be demonstrated in extracts. The arginine-utilizing system (aut) is apparently controlled like the enzymes responsible for the degradation of histidine (hut) through induction, catabolite repression, and activation by glutamine synthetase.
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