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  • Book
    Kostas N. Priftis, Leontios J. Hadjileontiadis, Mark L. Everard, editors.
    Summary: This book offers up-to-date information on the recording and analysis of respiratory sounds that will assist in clinical routine. The opening sections deliver basic knowledge on aspects such as the physics of sound and sound transmission in the body, a clear understanding of which is key to good clinical practice. Current techniques of breath sound analysis are described, and the diagnostic impact of advances in the processing of lung sound signals is carefully explained. With the aid of audio files that are available online, detailed guidance is then provided on differentiation of normal and abnormal breath sounds and identification of the various sounds, including crackles, wheezes, other lung sounds, cough sounds, and sounds of extrathoracic origin. The book is of high educational value and represents an excellent learning tool at pre- and postgraduate levels. It will also appeal to researchers as it provides comprehensive summaries of knowledge in particular research fields. The editors bring high-level expertise to the subject, including membership of the European Respiratory Society Task Force on the standardization of categories and nomenclature for breath sounds.
    Digital Access Springer 2018
  • Article
    Schlipköter HW, Krause GH, Stiller-Winkler R, Brockhaus A.
    Zentralbl Bakteriol Orig B. 1977 Dec;165(3-4):251-9.
    Groups of female NMRI-mice inhaled nine weeks 12.4 or 81.8 microgram Pb/m3 24 h per week, while other groups inhaled 0.3 mg NO2 + 5 mg flame soot/m3 or 5 mg NO2 + 0.3 mg flame soot/m3 for 45 h/week. Five animals of each group were randomly selected in weekly intervals and bacterial elimination determined 5 hours after inhaling a Serratia marcescens-aerosol. Bacteria in lung sections were determined by means of the "sandwich-method", using an anti-Serratia-serum and a FITC-loaded antirabbit-gammaglobuline. Inhalation of leadchloride caused a time and dose-dependent deterioration of bacterial elimination, which showed to be statistically significant already after three days of treatment with 81.8 microgram Pb/m3. A time dependent function between bacterial elimination and exposure could not be shown under treatment of the mixed pollutants NO2 and flame soot, although the lung clearance was deteriorated especially in the group treated with 5 mg NO2 + 0.3 mg flame-soot/m3. The experiments give evidence that lead exhibits a cyto-toxic effect on alveolar macrophages while the combined pollutants NO2 and flame-soot exhibit their adverse effect on the mucociliary-system. Nitrogen dioxide is shown to be a more hazardous pollutant than flame-soot within the given combination.
    Digital Access Access Options