BookFabian Kiessling, Bernd J. Pichler, Peter Hauff, editors.
Summary: This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.
Contents:
Role of small animal imaging. Noninvasive imaging for supporting basic research / Pat Zanzonico
Non-invasive imaging in the pharmaceutical industry / Sally-Ann Ricketts, Paul D. Hockings, John C. Waterton
How to set up a small animal imaging unit / David Stout
Noninvasive small rodent imaging: significance for the 3R principles / Nicolau Beckmann, Peter Maier
Study planning and animal preparation. Institutional preconditions for small animal imaging / René H. Tolba
Statistical considerations for animal imaging studies / Hannes-Friedrich Ulbrich
Animal anesthesia and monitoring / Marc Hein, Anna B. Roehl, René H. Tolba
Drug administration / Klaus Nebendahl, Peter Hauff
Imaging modalities and probes. How to choose the right imaging modality / Fabian Kiessling, Bernd J. Pichler, Peter Hauff
X-ray and X-ray-CT / Willi A. Kalender, Paul Deak, Klaus Engelke, Marek Karolczak
Ct contrast agents / Hubertus Pietsch
Small animal magnetic resonance imaging: basic principles, instrumentation and practical issue / Peter Jakob
Mr contrast agents / Eliana Gianolio, Alessandra Viale, Daniela Delli Castelli, Silvio Aime
Mr spectroscopy / Markus Becker
Ultrasound / Stuart Foster, Catherine Theodoropoulos
Ultrasound contrast agents / Michel Schneider
Imaging modalities and probes. PET and SPECT / Sibylle I. Ziegler
Radiotracer I: standard tracer / Walter Mier, Uwe Haberkorn
Radiotracer II: peptide-based radiopharmaceuticals / Roland Haubner, Clemens Decristoforo
Optical imaging / Ralf B. Schulz, Vasilis Ntziachristos
Optical probes / Kai Licha
Multi-modal imaging and image fusion / Vesna Sossi
Ex vivo validation methods. Ex vivo and in vitro cross calibration methods / Albertine Dubois, Julien Dauguet, Thierry Delzescaux
In vitro methods for in vivo quantitation of PET and SPECT imaging probes: autoradiography and gamma counting / David Stout
Data postprocessing. Qualitative and quantitative data analysis / Felix Gremse, Volkmar Schulz
Guidelines for nuclear image analysis / Martin S. Judenhofer, Stefan Wiehr, Damaris Kukuk, Kristina Fischer, Bernd J. Pichler
Kinetic modelling / J̲örg van den Hoff
Data documentation systems / S̲nke H. Bartling, Wolfhard Semmler
Special applications. Imaging in developmental biology / Katrien Vandoorne, Stav Sapoznik, Tal Raz, Inbal Biton, Michal Neeman
Imaging in gynecology research / Matthias W. Laschke, Michael D. Menger
Imaging in cardiovascular research / Michael Schäfers, Klaus Tiemann, Michael Kuhlmann, Lars Stegger, Klaus Schäfers, Sven Hermann
Imaging in neurology research I: neurooncology / Yannic Waerzeggers, Parisa Monfared, Alexandra Winkeler, Thomas Viel, Andreas H. Jacobs
Imaging in neurology research II: PET imaging of cns disorders / Gjermund Henriksen, Alexander Drzezga
Special applications / Imaging in Neurology Research III: Focus on Neurotransmitter Imaging / Wynne K. Schiffer
Imaging in oncology research / Wolfgang A. Weber, Fabian Kiessling
Imaging in immunology research / Jason T. Lee, Evan D. Nair-Gill, Brian A. Rabinovich, Caius G. Radu, Owen N. Witte.