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- BookPeter H. Wiernik, Janice P. Dutcher, Morie A. Gertz, editors.Summary: The new edition of this textbook integrates the history, epidemiology, pathology, pathophysiology, therapeutics, and supportive care of modern neoplastic hematopathology. Now in its sixth edition, this classic and invaluable text brings together a team of internationally renowned experts and offers in-depth coverage of the complex interface between diagnosis and therapy. The textbook is divided into five major sections, with the first four covering the spectrum of hematologic neoplasia, including chronic leukemias and related disorders, acute leukemias, myeloma and related disorders, and lymphomas, and the fifth section covering a variety of topics in supportive care. Chapters are presented in an accessible and easy-to-read layout, providing updates on the tremendous progress made in the last decade in the understanding of the nature of hematologic malignancies and their treatment. Neoplastic Diseases of the Blood, Sixth Edition is an authoritative and indispensable resource for students, trainees, and clinicians, sure to distinguish itself as the definitive reference on this subject.
Contents:
A History of the Chronic Leukemias
Epidemiology and Etiology of Chronic Myeloid Leukemia
Pathology of the Chronic Myeloid Leukemias
Molecular Biology and Cytogenetics of Chronic Myeloid Leukemia
Diagnosis and Treatment of Chronic Myeloid Leukemia
Etiology and Epidemiology of CLL
Morphology and Immunophenotype of CLL
The Genomic and Epigenomic Landscape of Chronic Lymphocytic Leukemia
Treatment of Chronic Lymphocytic Leukemia and Related Disorders
Hairy Cell Leukemia
History of Acute Leukemia
The Etiology of Acute Leukemia
Epidemiology and Hereditary Aspects of Acute Leukemia
Classification of the Acute Leukemias: Cytochemical and Morphologic Considerations
Immunobiology of Acute Leukemia
Cytogenetics of Acute Leukemia
Diagnosis and Treatment of Childhood Acute Lymphoblastic Leukemia
Diagnosis and Treatment of Adult Acute Lymphocytic Leukemia
Diagnosis and Treatment of Acute Myeloid Leukemia in Children
Diagnosis and Treatment of Adult Acute Myeloid Leukemia Other than Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
Therapy-Related Acute Myelogenous Leukemia
The Myelodysplastic Syndromes
History of Multiple Myeloma
Monoclonal Gammopathy of Undetermined Significance
Smoldering Multiple Myeloma
Newly Diagnosed Multiple Myeloma in Frail Patients
Newly Diagnosed Multiple Myeloma in Transplant Eligible Patients
Role of Hematopoietic Cell Transplantation for Myeloma
Solitary Plasmacytomas and Soft-Tissue Involvement in Multiple Myeloma
Supportive Care in Multiple Myeloma
POEMS Syndrome
Waldenstrom's Macroglobulinemia
Plasma Cell Leukemia
Prognosis of Myeloma/Genetics of Myeloma
Immunoglobulin Light Chain Amyloidosis (AL)
Historical Landmarks in an Understanding of the Lymphomas
Genetics in Lymphomagenesis
Epidemiology and Hereditary Aspects of Hodgkin and Non-Hodgkin Lymphomas
Pathology of Non-Hodgkin and Hodgkin Lymphomas
Immunology of the Lymphomas
Cytogenetics of Lymphomas
Diagnosis and Treatment of Hodgkin Lymphoma
Radiotherapeutic Management of Lymphomas
Diagnosis and Treatment of Non-Hodgkin's Lymphoma of Adults
Non-Hodgkin Lymphoma of Childhood
Lymphoma in Other Diseases
Supportive Care for Patients with Leukemia: A Historical Perspective
Prevention of Infections in Patients with Hematological Malignancies
Evaluation and Management of Bacterial and Fungal Infections in Patients with a Hematological Malignancy: A 2016 Update
Viral Infections in Patients with Hematological Malignancies
Therapeutic Cytapheresis, Plasmapheresis, and Plasma Exchange in Neoplastic Diseases of the Blood
Red Cell Transfusions in Patients with Hematologic Malignancies
Platelet and Granulocyte Transition
Alternative Sources of Hematopoietic Stem Cells and Their Clinical Applications
HLA Typing in Support of Hematopoietic Cell Transplantation from Unrelated Donors
Special Care of Blood and Marrow Hematopoietic Cell Transplant Recipient
Hematopoietic Growth Factors in the Supportive Care and Treatment of Patients with Hematologic Neoplasms
Bleeding and Thrombosis in Hematologic Neoplasia
Psychological Aspects of Hematological Neoplasms. - ArticleSzepesi T, Kärcher KH.Strahlentherapie. 1977 Dec;153(12):832-6.Today the endocrin therapy of the advanced mastocarcinoma is in common use. Besides the already known therapy by estrogens, androgens, gestagens, and steroids, Tamoxifen, and estrogen antagonist, is a very promising therapeutic drug. In the presented study, Tamoxifen was submitted to a critical clinical control during a period of one year from 1st October 1975 until 1st October 1976. After a three months' treatment, a rate of 41% of objective remissions could be obtained. The criteria of success were estimated according to the scheme of Karnofsky. The average remission time is 5,5 months. By a determination of the estrogen receptors it would be possible to realize a therapeutic selection and to achieve a higher remission rate. The authors made an interesting observation, i.e. a probably immuno-stimulating effect which, however, still has to be submitted to further examinations. The side effects are described in detail and the indications are established. Its is astonishing that the subjective ameliorations, i.e. cessation of pains in case of generalized formation of metastases in the bones are much more frequent than the objective remissions. We came to the conclusion that the treatment by Tamoxifen is a valuable alternative in the therapy of the mastocarcinoma, above all in the postmenopausal period if the disease is advanced and incurable.