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  • Book
    Ron El-Hawary, Craig P. Eberson, editors.
    Summary: Comprised exclusively of clinical cases demonstrating the management of idiopathic, congenital, syndromic and neuromuscular early onset scoliosis (EOS), this concise, practical casebook will provide orthopedic surgeons with the best real-world strategies to properly manage the differing presentations of EOS they may encounter. Each chapter is a case that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and management techniques used to treat it, as well as the case outcome, clinical pearls and pitfalls, and literature review. Cases included illustrate different types and management strategies for EOS, including various spine-based growing rods, the vertical expandable prosthetic titanium rib (VEPTR), anterior vertebral body tethering (AVBT) and congenital resection. Treatment strategies for EOS with related conditions such as myelomeningocele, cerebral palsy and skeletal dysplasia are also discussed, as are common complications and the role of traction. Pragmatic and reader-friendly, Early Onset Scoliosis: A Clinical Casebook is an excellent resource for pediatric orthopedic surgeons and other physicians confronted with both common and complex disorders of the child's spine.

    Contents:
    Normal Spine Growth
    Classification of Early Onset Scoliosis
    EDF Casting for Early Onset Scoliosis
    Spine-Based Growing Rods for the Treatment of Idiopathic Early Onset Scoliosis
    The Vertical Expandable Prosthetic Titanium Rib (VEPTR) for Idiopathic Early Onset Scoliosis
    Treatment of Idiopathic Early Onset Scoliosis with a Hybrid Growing Rod Construct
    Shilla Growth Guidance Technique for Early Onset Scoliosis
    Early Onset Scoliosis Treated with Magnetically Controlled Growing Rods
    Modern Trolley Growth Guidance for Early Onset Scoliosis
    Anterior Vertebral Body Tethering (AVBT) for Early Onset Scoliosis
    Anterior Vertebral Body Stapling for the Treatment of Idiopathic Scoliosis
    Congenital Resection for Early Onset Scoliosis
    The Vertical Expandable Prosthetic Titanium Rib (VEPTR) for Congenital Scoliosis
    Hemiepiphysiodesis for the Treatment of Congenital Scoliosis
    Congenital Myopathy with Early Onset Scoliosis
    Cerebral Palsy with Early Onset Scoliosis
    The Use of the Vertical Expandable Prosthetic Titanium Rib (VEPTR) in Myelomeningocele
    Early Onset Scoliosis in Skeletal Dysplasia
    Complications with Early Onset Scoliosis
    Spine Growth Assessment of Growth Friendly Surgery
    The Role of Traction in Early Onset Scoliosis
    The End Game for Early Onset Scoliosis.
    Digital Access Springer 2018
  • Article
    Dodi G, Santoro MG, Jaffe BM.
    Surgery. 1978 Feb;83(2):206-13.
    The effect of 16,16-dimethyl PGE2-methyl-ester (di-M-PGE2, a long-acting synthetic analogue of PGE2) on exocrine and endocrine pancreatic secretion was studied in rats with chronic pancreatic fistulas. Under basal conditions as well as after stimulation with secretin and OP-CCK, pancreatic exocrine secretion was inhibited markedly by intravenous injection of di-M-PGE2 at 10 microgram/kg and 100 microgram/kg. Secretory volumes and bicarbonate and protein outputs decreased within 10 minutes after the administration of di-M-PGE2, and this inhibitory effect persisted throughout the following 40 minutes. The smaller dose of di-M-PGE2 (10 microgram/kg) inhibited the volume of pancreatic secretion by an average of 47.7% and decreased bicarbonate and protein output by 41.1% and 70.5%, respectively. The larger dose (100 microgram/kg) caused a mean 48.3% inhibition of pancreatic secretory volume and decreased bicarbonate and protein outputs by 41.7% and 64.5%, respectively. Plasma insulin levels were lowered markedly after injection of di-M-PGE2 under basal conditions (mean inhibition 63.1% by PG-10 and 55.3% by PG-100) as well as after secretin stimulation (mean inhibition 89.5% by PG-10 and 82.4% by PG-100). These observations document that di-M-PGE2 is a potent inhibitor of pancreatic exocrine and endocrine function in the unanesthetized rat. In these actions the PGE2-analogue antagonized the stimulatory effects of both secretin and OP-CCK.
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