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- BookBari M. Logan, Patricia A. Reynolds, Scott Rice ; original photography by Ralph T. Hutchings.Contents:
Skull, skull bone articulations and teeth
Cervical vetebrae and neck
Face, orbit and eye
Nose, oral cavity, pharynx, ear and larynx
Cranial cavity and brain
Clinical imaging.Digital Access ClinicalKey 2017 - ArticleFielding J.Scand J Haematol Suppl. 1977;32:100-4.Several factors influence the induction of sarcomas at the site of iron carbohydrate complex injection in high dosage, in animals. 1. Species specificity: tumours have been induced in rats, mice and hamsters but not in guinea pigs or dogs; 2. dose-response: a threshold dose may be defined and the yield of tumours increases with the dose; 3. the amount of residual iron at the injection site: the effect is a local oncogenesis; 4. the latent period relative to life span in the species: the probable latent period in man has been estimated to be 15-20 years. Since iron-dextran was introduced 22 years ago, nine malignancies in man allegedly related to iron-complex injection have been described in five reports during the period 1960-1977. A critical review of the information available on these cases suggests that in one case only is the data sufficiencyl strong to support the probability of iron-dextran induced sarcoma in man. Soft tissue tumours of the buttock are not rare: on the basis of this single case a causal relationship in man cannot yet be made.