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  • Book
    Angelo Raffaele De Gaudio, Stefano Romagnoli, editors.
    Summary: This book provides a practical and comprehensive guide to delivering analgesia and sedation to critically ill patients for professionals and caregivers being involved in the management of these patients. It discusses and explains in detail the advantages and limitations of each drug and device using clear flowcharts, diagrams and tables. Furthermore, it explores the new drugs and - above all - new sedation delivery systems, particularly those for administering volatile anesthetics on ICUs. Written by respected experts in the field, this book is a valuable and practical resource for anesthesists, intensivists and emergency physicians interested in sedation.

    Contents:
    Introduction
    The Stress Response
    Pain management in Critically Ill Patients
    Common Practice and Guidelines for Sedation in Critically Ill Patients
    Clinical and Instrumental Measures of Sedation
    Intravenous Sedatives and Analgesics
    Volatile Anesthetics
    Regional Anesthesia Techniques for Pain Control Critically ill Patients
    Neuromuscolar¬ocking Agents
    Sedation and Hemodynamics
    Sedation and Immune System
    Sleep in the ICU
    Delirium in Critically Ill Patients
    Sedation in pediatric Critically Ill Patients
    Sedation in Cardiac Surgery Intensive Care Unit.
    Digital Access Springer 2018
  • Article
    Chattopadhyay PK, Wu HC.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5318-22.
    Biosynthesis of the diglyceride moiety of murein lipoprotein in Escherichia coli was studied by pulse-labeling with [2-3H]glycerol and subsequent chase. The evidence strongly suggests that the precursor of the glycerol moiety in lipoprotein is one of the major phospholipid species in E. coli. Studies of biosynthesis of lipoprotein in cerulenin-treated cells indicated that the nonacylated glycerol moiety of phosphatidylglycerol is the donor for the formation of a thioether linkage in the glycerylcysteine residue of the lipoprotein. This is supported by the observation that carbon 1 rather than carbon 3 of sn-glycerol is involved in this thioether linkage. We propose that the biosynthesis of lipoprotein proceeds as follows: apolipoprotein + phosphatidylglycerol or acyl phosphatidylglycerol leads to lipoprotein + phosphatidic acid.
    Digital Access Access Options