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  • Book
    David J. Hass, editor.
    Summary: This volume provides a comprehensive introduction and review of small bowel capsule endoscopy (SBCE). The book reviews the data regarding appropriate indications and contraindications for the implementation of small bowel capsule endoscopy, while discussing in detail the evolving role of SBCE in the treatment of obscure gastrointestinal bleeding, and the management of inflammatory bowel disease, small bowel polyposis syndromes, and refractory malabsorption. Topics such as complications of SBCE, methods to perform SBCE on patients with dysphagia or gastric emptying pathology, and understanding the normal anatomy of the gastrointestinal tract when viewed via SBCE are also discussed. In addition, an introduction to colon capsule technology and the next generation of small bowel capsule imaging is reviewed. The text is complemented by several illustrative cases that are demonstrated with both online full length videos as well as an online interactive companion that includes review questions to reinforce concepts learned in the text. Written by experts in the field, Capsule Endoscopy: A Guide to Becoming an Efficient and Effective Reader is an invaluable resource for novice capsule endoscopy readers, fellows in gastroenterology and hepatology, researchers, mid-level providers, residents, and medical students with an interest in learning how to implement and perform SBCE in the investigation of small bowel diseases.

    Contents:
    The History and Development of the Small Bowel Capsule/Comparison of Current Available Capsule Platforms
    SBCE Indications and Contraindications? and the Logistics of Administering the Capsule? Preps, Prokinetics, Retention
    Difficult Populations? Dysphagia/Partial SBOs/ICDs/Pediatrics
    Capsule Endoscopy for Obscure Ganstrointestinal Bleeding.-The Utility of Capsule Endoscopy in Crohn?s disease
    The Role of Capsule Endoscopy in the Diagnosis and Management of Celiac Disease and Refractory Diarrhea
    Becoming an Efficient and Effective Reader of Capsule Endoscopy in Screening and Surveillance of Small Bowel Polyposis Syndromes and Masses
    How to Read a Small Bowel Capsule Endoscopy Study
    Normal versus Abnormal CE Images
    Colon Capsule and the Future of Capsule Endoscopy.
    Digital Access Springer 2017
  • Book
    [zusammengestellt und bearbeitet von Walter Tölg].
    Print c1987
  • Article
    Kaplan MM, Utiger RD.
    J Clin Invest. 1978 Feb;61(2):459-71.
    To investigate mechanisms of extrathyroidal thyroid hormone metabolism, conversion of thyroxine (T(4)) to 3,5,3'-triiodothyronine (T(3)) and degradation of 3,3',5'-triiodothyronine (rT(3)) were studied in rat liver homogenates. Both reactions were enzymatic. For conversion of T(4) to T(3), the K(m) of T(4) was 7.7 muM, and the V(max) was 0.13 pmol T(3)/min per mg protein. For rT(3) degradation, the K(m) of rT(3) was 7.5 nM, and the V(max) was 0.36 pmol rT(3)/min per mg protein. Production of rT(3) or degradation of T(4) or T(3) was not detected under the conditions employed. rT(3) was a potent competitive inhibitor of T(4) to T(3) conversion with a K(i) of 4.5 nM; 3,3'-diiodothyronine was a less potent inhibitor of this reaction. T(4) was a competitive inhibitor of rT(3) degradation with a K(i) of 10.2 muM. Agents which inhibited both reactions included propylthiouracil, which appeared to be an allosteric inhibitor, 2,4-dinitrophenol, and iopanoic acid. Sodium diatrizoate had a weak inhibitory effect. No inhibition was found with alpha-methylparatyrosine, Fe(+2), Fe(+3), reduced glutathione, beta-hydroxybutyrate, or oleic acid. Fasting resulted in inhibition of T(4) to T(3) conversion and of rT(3) degradation by rat liver homogenates which was reversible after refeeding. Serum T(4), T(3), and thyrotropin concentrations fell during fasting, with no decrease in serum protein binding as assessed by a T(3)-charcoal uptake. There was no consistent change in serum rT(3) concentrations. Dexamethasone had no effect in vitro. In vivo dexamethasone administration resulted in elevated serum rT(3) concentrations after 1 day, and after 5 days, in inhibition of T(4) to T(3) conversion and rT(3) degradation without altering serum T(4), T(3), or thyrotropin concentrations. Endotoxin treatment had no effect of iodothyronine metabolism in liver homogenates. In kidney homogenates the reaction rates and response to propylthiouracil in vitro were similar to those in liver. No significant T(4) to T(3) conversion or rT(3) production or degradation could be detected in other tissues. These data suggest that one iodothyronine 5'-deiodinase is responsible for both T(4) to T(3) conversion and rT(3) degradation in liver and, perhaps, in kidney. Alterations in serum T(3) and rT(3) concentrations induced by drugs and disease states may result from decreases in both T(3) production and rT(3) degradation consequent to inhibition of a single reaction in the pathways of iodothyronine metabolism.
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