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- BookPeter R. Hoskins, Patricia V. Lawford, Barry J. Doyle, editors.Summary: This book provides a balanced presentation of the fundamental principles of cardiovascular biomechanics research, as well as its valuable clinical applications. Pursuing an integrated approach at the interface of the life sciences, physics and engineering, it also includes extensive images to explain the concepts discussed. Cardiovascular biomechanics encompasses the relationship between the mechanics of the cardiovascular system and biological function in health and disease, and it is increasingly recognised that normal function and diseases involve a complex interplay between biology and mechanical forces. With a focus on explaining the underlying principles, this book examines the physiology and mechanics of circulation, mechanobiology and the biomechanics of different components of the cardiovascular system, in-vivo techniques, in-vitro techniques, and the medical applications of this research. Written for undergraduate and postgraduate students and including sample problems at the end of each chapter, this interdisciplinary text provides an essential introduction to the topic. It is also an ideal reference text for researchers and clinical practitioners, and will benefit a wide range of students and researchers including engineers, physicists, biologists and clinicians who are interested in the area of cardiovascular biomechanics.
Contents:
Introduction to fluid and solid mechanics
Introduction to biomechanics of the cardiovascular system
Blood and blood flow
Arterial biomechanics I. Pressure, flow and stiffness
Arterial biomechanics II. Forces, adaptability and mechanotransduction
Excitation-contraction in the heart
Biomechanics of the venous system
Biomechanics of the microcirculation
Medical imaging
Modelling of the cardiovascular system
Patient specific modelling
Flow phantoms
Measurement of the mechanical properties of biological tissues
Hypertension
Atherosclerosis
Aneurysms
Cardiovascular prostheses
Appendix 1: Questions
Appendix 2: Glossary
Index. - ArticleBouché JP, Rowen L, Kornberg A.J Biol Chem. 1978 Feb 10;253(3):765-9.With phage G4 DNA as template, primase (the dnaG protein) synthesizes a 26- to 29-residue RNA transcript at the origin of replication. The sequence starts with ATP and contains a hairpin region of one A-U and seven G-C base pairs. Covalent linkage between the RNA and the newly synthesized complementary DNA chain indicates that the RNA transcript serves as a primer.