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- BookJon Kobashigawa, editor.Summary: This handbook is an easy reference for those involved in the management of heart transplant. While this compilation of best practices cannot address the complexity of the individual patients we care for on a daily basis, it will serve to help us ask the right questions, access the best evidence and ultimately make the best decisions for the patients involved. Clinical Guide to Heart Transplantation provides a current review of the field of heart transplantation and how it has evolved into an established therapy for the treatment of end-stage heart failure. With the advent of improved surgical techniques, the development of immunosuppressive drugs and the utilization of more sophisticated monitoring strategies and treatments for graft rejection, heart transplantation now offer patients an avenue to both improved survival and quality of life. With over 4000 heart transplants performed per year globally and with 1-year survival approaching 90%, this practical title assists those involved in the this most complex of procedures to establish best practice. It is therefore essential reading for all practitioners in this field, charged with making critical decisions in the management of patients, donor organs, and the transplant process itself in order to achieve the greatest benefit in the utilization of this often scarce resource.
Contents:
Introduction
Options for Patients with End-Stage Heart Failure
Evaluation of Heart Transplant Candidacy
Listing Criteria and Process
Optimal Management of Patients on the Heart Transplant Waiting List
Histocompatibility Testing and Cross Matching
The Sensitized Patient Awaiting Heart Transplantation
Donor Organ Preservation and Surgical Considerations in Heart Transplantation
Immediate Post-Operative Period
Immunosuppression Strategies in Heart Transplantation
Rejection Surveillance and Treatment in the First Year
Out-Patient Management of the Heart Transplant Patient
Long-Term Complications in Heart Transplantation
The Total Artificial Heart
Chimerism and Tolerance
Genomics In Heart Transplantation
The Future of Heart Transplantation.Digital Access Springer 2017 - ArticleTanaka T, Kita H, Murakami T, Narita K.J Biochem. 1977 Dec;82(6):1681-7.Mating factor is a peptide excreted into the culture fluid by alpha-mating type cells of Saccharomyces cerevisiae X-2180 1B. The purification of the mating factor was carried out by ion exchange chromatography on phosphocellulose and Amberlite IRC 50 columns, followed by gel filtration on a Sephadex LH 20 column. The factor thus prepared was a peptide composed of Lys1, His1, Trp2, Gln2, Pro2, Gly1, Met1, Leu2 and Tyr1, and was able to induce morphological changes on alpha-mating type cells at a concentration of 5 pg/ml. The amino acid sequence of the mating factor was determined by the manual Edman degradation method using intact mating factor and its thermolytic peptides. The C-terminal amino acid residue was determined by digesting the factor with carboxypeptidase A. The complete amino acid sequence of the mating factor was established to be as follows: Trp-His-Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr.