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  • Book
    Juan Pedro Martinez-Barbera, Cynthia Lilian Andoniadou, editors.
    Summary: This astute volume brings together the latest expert research on adamantinomatous craniopharyngiomas (ACPs). ACPs are histologically benign but clinically aggressive tumors exhibiting a high propensity for local invasion into the hypothalamus, optic and vascular structures. These tumors, as well as the current treatments, may result in pan-hypopituitarism, diabetes insipidus, morbid obesity followed by type II diabetes mellitus, blindness, as well as serious behavioral and psychosocial impairments. Exploring in detail advances in both the understanding of tumor biology as well as clinical advances in patient management are explored in detail, this book will also look towards potential new treatment approaches. Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underlie the etiology of the majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke's pouch precursors. In addition, a role for tissue-specific adult pituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have been shown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy.
    Digital Access Springer 2017
  • Article
    Nowakowski TK, Scholz A.
    Hautarzt. 1977 Nov;28(11):593-9.
    Since the 16th century there are well documented examples for cases of hypertrichosis universalis. They are often confused with legends and stories of wild men. The patients were often shown at courtyards and later on at fairs. The observation of a new case of hypertrichosis universalis lanuginosa combines the description of hairiness and teeth with its psychical and physical development. Our patient was socially intergrated ones kept from outsider position.
    Digital Access Access Options