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  • Book
    Kiyoshi Makiyama, Shigeru Hirano, editors.
    Summary: "This book discusses the aging voice, one of the interesting issues related to aging. Population aging is an issue in most developed countries, where both physicians and specialists are required to improve clinical and scientific practice for elderly adults. In particular, the need for expertise in the diagnosis and treatment of aging voice pathologies is increasing continually. New developments in regenerative medicine have taken care for the aging voice to new level, and the contributors to this book use their wealth of experience in the field of the aging voice to present the latest advances in this field. This book is a unique resource, providing new perspectives for physicians, clinicians and health care workers who are interested in the aging voice."--Back cover.

    Contents:
    Overview / Shigeru Hirano
    Age-Related Histological Changes of the Vocal Folds / Masanobu Mizuta
    Age-Related Changes in the Human Voice / Hideki Kasuya and Hajime Yoshida
    Evaluation of Phonatory Function in the Elderly / Hiroumi Matsuzaki and Kiyoshi Makiyama
    Clinical Assessment of Elderly Vocal Folds by Laryngoscopy / Yoichiro Sugiyama
    Quantitative Analysis of High-Speed Digital Imaging for the Elderly / Akihito Yamauchi and Niro Tayama
    Collagen Injection for the Elderly with Dysphonia / Hiroumi Matsuzaki and Kiyoshi Makiyama
    Fat Injection for Voice Improvement in Atrophic Vocal Folds / Etsuyo Tamura
    Voice Therapy for the Elderly / Mami Kaneko
    Current Topics in Regenerative Medicine for the Laryngeal Tissues / Yo Kishimoto
    Future Prospects / Shigeru Hirano and Shin-ichi Kanemaru.
    Digital Access Springer 2017
  • Article
    Takigawa M, Hanaoka M.
    Int Arch Allergy Appl Immunol. 1978;56(2):115-22.
    Morphological changes of the splenic white pulp in athymic nude mice (nu/nu) and their normal littermates (nu/ + ) following intraperitoneal injection of bacterial lipopolysaccharide were studied by light and electron microscopy, immunofluorescence and autoradiography. Early blast formation and subsequent appearance of IgM-containing cells were observed by 72 h and at 120 h, respectively, in the periarteriolar sheath of nu/nu mice and in the follicular area of nu/ + mice. Ultrastructural details of blasts and the time course of their development were similar in both nu/nu and nu/ + mice. Lymphoblasts showed a large nucleus with a prominent nucleolus, many polysomes and poorly developed smooth endoplasmic reticulum. Plasmablasts had a nucleus with coarse heterochromatin and copious cytoplasm filled with dilated rough endoplasmic reticulum. Generally, lymphocytes proliferated and differentiated through lymphoblasts to plasmablasts by 72 h and finally to plasma cells at 120 h. However, this development was asynchronous since lymphoblasts, plasmablasts and plasma cells were observed simultaneously at 72 h. It was suggested that a B cell subset responsive to bacterial lipopolysaccharide matures to antibody-forming cells in the thymus-dependent area in nu/nu mice and in the thymus-independent area in nu/ + mice.
    Digital Access Access Options