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  Noninvasive Prenatal Testing (NIPT) : Applied Genomics in Prenatal Screening and Diagnosis

  edited by Lieve Page-Christiaens, Hanns-Georg Klein.

  Summary: "Since its introduction in 2012, cell-free (cf) DNA based Non-Invasive Prenatal Testing (NIPT) has been employed to test for fetal chromosome abnormalities, and gene mutations that lead to a variety of genetic conditions, by millions of pregnant women, in more than 90 countries worldwide. With Noninvasive Prenatal Testing (NIPT): Applied Genomics in Prenatal Screening and Diagnosis, Dr Lieve Page-Christiaens and Dr Hanns-Georg Klein have compiled the first authoritative volume on cfDNA NIPT methods and their clinical implementation"--Publisher's description.
  
  Contents:
  Section 1: Cell-freeDNA (CfDNA): overview and technology. Fetal DNA in maternal plasma: an amazing two decades
  Understanding the basics of next generation sequencing in the context of cell-free DNA based NIPT
  The technology and bioinformatics of cell-free DNA based NIPT
  Section 2: CfDNA in clinical practice. Prenatal screening for common aneuploidies before and after the introduction of cell-free DNA based NIPT
  Why cell-free DNA based NIPT for fetal chromosome anomalies is not diagnostic
  The role of cell-free DNA based NIPT in twin pregnancy
  Genomewide testing for autosomal trisomies and copy number variations
  Non-invasive fetal blood group typing
  Noninvasive prenatal diagnosis (NIPD) of monogenic disorders
  Maternal constitutional and acquired copy number variations (CNVs)
  Section 3: Clinical integration. Best practices for integrating cell-free DNA based NIPT into clinical practice
  Quality assurance and standardization of cell-free DNA based NIPT laboratory procedures
  Decisional support for expectant parents
  Cell-free DNA based NIPT and society
  Ethics of cell-free DNA based NIPT for sex chromosome aneuploidies and sex determination
  Cost-effectiveness of cell-free DNA based NIPT: summary of evidence and challenges
  Section 4: The future. Exome sequencing in the evaluation of the fetus with structural anomalies
  Cell-based NIPT: a promising path for prenatal diagnosis
  Maternal circulating nucleic acids as a marker of placental health
  Prenatal treatment of genetic diseases in the unborn

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• Article

  Nachuntersuchungsergebnisse zur Abstützung von Teilprothesen. [Results of follow-up studies on support methods for partial dentures].

  Kerschbaum T.

  Dtsch Zahnarztl Z. 1977 Dec;32(12):971-5.

  Prosthetic provision with removable part-replacement was divided into 7 groups according to the type of support and the prognosis was established on the basis of caries activity and several criteria of the periodontal condition, separated according to anchoring or supporting teeth as well as the remaining teeth. Generally regressive changes must be expected which become more marked with reduction in the number of teeth and support possibilities.

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  PubMed