Search

Search Results

• Book

  Stromal Immunology

  Benjamin M.J. Owens, Matthew A. Lakins, editors.

  Digital Access Springer 2018
  Get Shareable Link

  View Details
• Article

  Vliianie metilkobalamina i ftoralkilkobalaminov na rost kletok E. coli 113/3 i pervichnuiu kul'turu émbrional'nykh fibroblastov cheloveka. [Effect of methylcobalamin and fluoralkylcobalamins on E. coli 113/3 cell growth and on a primary human embryonic fibroblast culture].

  Miasishcheva NV, Golenko OD, Kuznetsova LE, Raushenbakh MO, Rudakova IP.

  Vopr Med Khim. 1977 Sep-Oct;23(5):622-9.

  Comparative analysis of the functional activity of several fluoralkylcobalamines was carried out using E. coli 113/3 strain deficient in vitamin B12 and methionine. Difluoro chlor methylcobalamine (CF2Cl-Cbl) exhibited the most distinct inhibitory effect on growth of bacterial cells in the medium with cobalamine. Effect of methylcobalamine and CF2Cl-Cbl on the proliferative activity of human embryonal fibroblasts was studied in media of various composition. The proliferative activity of fibroblasts was distinctly increased in the medium with methylcobalamine at various periods of cultivation; the fraction of 3H-thimidine labelled cells and the mitotic index were increased. The distinct decrease in amount of cells, synthesizing DNA, and in their mitotic activity was observed in medium with CF2Cl-Cbl. The data obtained suggest that difluorochlor methylcobalamine affects the cell proliferation as the antagonist of methylcobalamine in experiments with bacterial cells and the primary culture of human embryonal fibroblasts.

  Digital Access Access Options
  Get Shareable Link

  PubMed